Expression and clinical significance of endoplasmic reticulin 29 and driver protein superfamily 23 in esophageal carcinoma cancer
Objective To study the expression level of endoplasmic reticulum protein 29(ERp29)and kinesin family member 23(KIF23)in esophageal cancer tissues and analyze the relationship between ERp29 and KIF23 and clinicopathological factors of esophageal cancer.Methods Immunohistochemical methods were used to detect the expression of ERp29 and KIF23 in cancer tissues and adjacent esophageal tissues of 77 patients with esophageal cancer admitted to Affiliated Hospital of Guangdong Medical Universi-ty from April 2020 to August 2023.Chi-square test was used to evaluate the relationship between the ex-pression of ERp29 and KIF23 and the clinicopathological features of esophageal cancer.Results The ex-pression rate of ERp29 in esophageal cancer tissues was 48.05%(37/77),which was significantly lower than that in adjacent esophageal tissues[81.82%(63/77)](x2=19.279,P<0.01).There were no sig-nificant correlation between the expression level of ERp29 and the gender,age and histological differentia-tion of patients with esophageal cancer(respectively,x2=0.019,0.024,0.499,P>0.05).The expres-sion level of ERp29 was significantly correlated with TNM stage and lymph node metastasis(respectively,x=4.872,5.758,P<0.05).The expression rate of KIF23 in esophageal cancer tissues was 62.34%(48/77),which was significantly higher than that in adjacent esophageal tissues[15.58%(12/77)](x2=35.387,P<0.01).There was no significant correlation between KIF23 expression level and gender and age of patients with esophageal cancer(respectively,x=0.043,0.009,P>0.05).The expression level of KIF23 was significantly correlated with histological differentiation,TNM stage and lymph node me-tastasis(respectively,x2=6.634,5.991,4.114,P<0.05).Conclusion The expression of ERp29 is low,and the expression of KIF23 is high in esophageal cancer tissue.ERp29 and KTF23 play an important role in the progression and prognosis of esophageal cancer.
Immunohistochemical methodEndoplasmic reticulum protein 29Esophageal cancerKinesin family member 23