首页|内质网蛋白29和驱动蛋白超家族23在食管癌组织中的表达及其临床意义

内质网蛋白29和驱动蛋白超家族23在食管癌组织中的表达及其临床意义

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目的 观察食管癌组织中内质网蛋白29(ERp29)和驱动蛋白超家族23(KIF23)的表达,分析ERp29和KIF23与食管癌临床病理因素的关系.方法 以2020年4月至2023年8月广东医科大学附属医院收治的77例食管癌患者的癌组织和癌旁组织标本作为研究对象,采用免疫组织化学法检测食管癌组织和癌旁组织中ERp29和KIF23表达,应用x2检验评价ERp29和KIF23的表达与食管癌临床病理特征的关系.结果 食管癌组织中ERp29表达率48.05%(37/77),明显低于癌旁组织中ERp29表达率81.82%(63/77),差异具有统计学意义(x2=19.279,P<0.01).ERp29表达水平与食管癌患者性别、年龄、组织学分化程度无明显相关(x2=0.019、0.024、0.499,P>0.05),ERp29表达水平与食管癌患者TNM分期、淋巴结转移明显相关(x2=4.872、5.758,P<0.05).食管癌组织中KIF23表达率62.34%(48/77),明显高于癌旁组织中KIF23表达率15.58%(12/77),两者比较差异有统计学意义(x2=35.387,P<0.01).KIF23表达水平与食管癌患者性别、年龄无明显相关(x2=0.043、0.009,P>0.05),KIF23表达水平与食管癌患者组织学分化程度、TNM分期、淋巴结转移明显相关(x2=6.634、5.991、4.114,P<0.05).结论 ERp29在食管癌组织中低表达、KIF23在食管癌组织中高表达,ERp29和KIF23在食管癌的进展和预后中起重要作用.
Expression and clinical significance of endoplasmic reticulin 29 and driver protein superfamily 23 in esophageal carcinoma cancer
Objective To study the expression level of endoplasmic reticulum protein 29(ERp29)and kinesin family member 23(KIF23)in esophageal cancer tissues and analyze the relationship between ERp29 and KIF23 and clinicopathological factors of esophageal cancer.Methods Immunohistochemical methods were used to detect the expression of ERp29 and KIF23 in cancer tissues and adjacent esophageal tissues of 77 patients with esophageal cancer admitted to Affiliated Hospital of Guangdong Medical Universi-ty from April 2020 to August 2023.Chi-square test was used to evaluate the relationship between the ex-pression of ERp29 and KIF23 and the clinicopathological features of esophageal cancer.Results The ex-pression rate of ERp29 in esophageal cancer tissues was 48.05%(37/77),which was significantly lower than that in adjacent esophageal tissues[81.82%(63/77)](x2=19.279,P<0.01).There were no sig-nificant correlation between the expression level of ERp29 and the gender,age and histological differentia-tion of patients with esophageal cancer(respectively,x2=0.019,0.024,0.499,P>0.05).The expres-sion level of ERp29 was significantly correlated with TNM stage and lymph node metastasis(respectively,x=4.872,5.758,P<0.05).The expression rate of KIF23 in esophageal cancer tissues was 62.34%(48/77),which was significantly higher than that in adjacent esophageal tissues[15.58%(12/77)](x2=35.387,P<0.01).There was no significant correlation between KIF23 expression level and gender and age of patients with esophageal cancer(respectively,x=0.043,0.009,P>0.05).The expression level of KIF23 was significantly correlated with histological differentiation,TNM stage and lymph node me-tastasis(respectively,x2=6.634,5.991,4.114,P<0.05).Conclusion The expression of ERp29 is low,and the expression of KIF23 is high in esophageal cancer tissue.ERp29 and KTF23 play an important role in the progression and prognosis of esophageal cancer.

Immunohistochemical methodEndoplasmic reticulum protein 29Esophageal cancerKinesin family member 23

刘涛、杨绍修、苏艳婷、黄先进

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广东医科大学附属医院乳腺食管肿瘤专科,湛江 524001

广东医科大学附属医院胃肠外科,湛江 524001

免疫组织化学法 内质网蛋白29 食管癌 驱动蛋白超家族23

2024

中华实验外科杂志
中华医学会

中华实验外科杂志

CSTPCD
影响因子:0.759
ISSN:1001-9030
年,卷(期):2024.41(2)
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