循环肿瘤细胞在肺肿瘤患者诊疗中的应用价值
Application value of circulating tumor cells in the diagnosis and treatment of lung tumor patients
王佳琦 1班金豹 1刘霞 1赵志超1
作者信息
- 1. 郑州大学第一附属医院胸外科,郑州 450052
- 折叠
摘要
目的 分析循环肿瘤细胞(CTC)在肺肿瘤患者诊疗中的临床应用价值.方法 选取郑州大学第一附属医院胸外科2020年4月至2022年4月收治的14例肺良性肿瘤患者和40例肺恶性肿瘤患者,通过配体靶向聚合酶链反应(PCR)法检测患者术前、术后1个月的CTC水平,分析外周血CTC水平与临床资料之间的关系,并对以上患者进行跟踪随访.应用x2检验、Willcoxon秩和检验和Cox回归进行数据分析.结果 肺恶性肿瘤患者组CTC阳性率高于肺良性肿瘤患者组[75.0％(30/40)比35.7％(5/14),x2=7.018,P＜0.05).CTC阳性表达率与性别、年龄、组织学类型无明显相关(x2=0.320、2.133、0.076,P＞0.05),而与肿瘤病理分期(x2=3.372,P＜0.001)及肿瘤最大径(x2=3.843,P＜0.001)明显相关.CTC阳性是肺癌患者术后转移复发的危险因素[风险比(HR):0.145,95％置信区间:0.031～0.685,P＜0.05].结论 肺癌患者的CTC水平与肿瘤TNM分期相关,有利于判断肺结节的性质,有助于肺肿瘤诊断,有助于预后评估及术后指导治疗.
Abstract
Objective To analyze the clinical application value of circulating tumor cells(CTCs)in the diagnosis and treatment of lung tumor patients.Methods A total of 14 patients with benign lung tumors and 40 patients with malignant lung tumors admitted to the thoracic surgery department of our hospi-tal from April 2020 to April 2022 were selected.The CTCs levels of patients before and one month after surgery were detected using ligand targeted polymerase chain reaction(PCR).The relationship between pe-ripheral blood CTCs levels and clinical data was analyzed,and the patients were followed up.Data were analyzed using chi-square test,Wilcoxon rank sum test,and Cox regression.Results The positive rate of CTCs in patients with malignant lung tumors was significantly higher than that in patients with benign lung tumors[75.0％(30/40)vs.35.7％(5/14),x2=7.018,P＜0.05].The positive expression rate of CTCs was not significantly correlated with gender,age and histological type(x2=0.320,2.133,0.076,P＞0.05),but with tumor pathological stage(x2=3.372,P＜0.001)and maximum diameter(x2=3.843,P＜0.001).Positive CTC was a risk factor for postoperative metastasis and recurrence in lung cancer patients[hazard ratio(HR):0.145,95％confidence interval(CI):0.031-0.685,P＜0.05].Conclusion The level of CTCs in lung cancer patients is correlated with tumor TNM staging,which is beneficial for determining the nature of lung nodules,aiding in the diagnosis of lung tumors,prognosis e-valuation,and postoperative guidance for treatment.
关键词
循环肿瘤细胞/肺肿瘤/诊断/预后Key words
Circulating tumor cell/Lung tumor/Diagnosis/Prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据