肿瘤引流淋巴结在免疫治疗中的作用研究进展
Development in immunotherapy of tumor draining lymph node
董小锋 1杨建荣 1李朋洋 1钟敬涛2
作者信息
- 1. 广西壮族自治区人民医院肝胆胰脾外科,南宁 530021
- 2. 山东省肿瘤防治研究院(山东省肿瘤医院)肝胆外科,山东第一医科大学(山东省医学科学院),济南 250117
- 折叠
摘要
肿瘤引流淋巴结(TDLN)是位于肿瘤下游的第一站淋巴结,也被称为前哨淋巴结,TDLN内免疫微环境改变引起免疫细胞活性的变化直接影响肿瘤细胞的活性及远处转移能力.免疫治疗目前是恶性肿瘤治疗的重要手段,TDLN内免疫微环境的变化与肿瘤免疫治疗的效果密切相关.本文就TDLN内免疫微环境的变化与肿瘤免疫治疗疗效的进展进行总结,为恶性肿瘤的免疫治疗提供思路.
Abstract
The tumor draining lymph node(TDLN)is the first lymph node located downstream of the tumor,also known as the sentinel lymph node.Immune cell activity changes caused by changes of immune microenvironment within TDLN directly impact the activity and the metastatic ability of tumor cells.Immunotherapy is currently an impor-tant therapy for the treatment of malignant tumors,and changes in the immune microenvironment within TDLN are closely related to the effectiveness of tumor immunotherapy.This paper summarizes the progress in the changes of the immune microenvironment within TDLN and the efficacy of tumor immunotherapy,providing new ideas for the immuno-therapy of malignant tumors.
关键词
恶性肿瘤/淋巴结/免疫治疗Key words
Malignant tumors/Lymph nodes/Immunotherapy引用本文复制引用
基金项目
国家自然科学基金(82160589)
山东省自然科学基金(ZR2023MH044)
南宁市青秀区科学技术局重点研发计划(2020035)
出版年
2024
NETL
NSTL
万方数据