Colorectal cancer(CRC)is a common malignant tumor of the digestive system and the second leading cause of cancer-related deaths.Epigenesis is one of the key factors that mediate the occur-rence and development of CRC,and the clinical transformation effect of the current target therapy based on histone/DNA methylation modification leaves much to be desired.In recent years,RNA modifications have become a new research frontier and hot spot in the field of epigenetics.With the wide application of large-sample multi-omics analysis and high-throughput sequencing technology in this field,it has been found that several RNA modification-related proteins have good independent prognostic value in CRC,and RNA modi-fications are closely involved in the malignant progression,chemotherapy resistance,and anti-tumor im-mune regulation of CRC.This article reviews the latest research progress of RNA modifications in CRC,ai-ming to understand the mechanism of RNA modifications in the malignant progression of CRC,in hope to provide new ideas and strategies for the treatment and prognosis of CRC.
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