RNA修饰在结直肠癌中的研究进展
Progress of RNA modification in colorectal cancer
马明真 1郑勇斌1
作者信息
- 1. 武汉大学人民医院胃肠外Ⅰ科,武汉 430061
- 折叠
摘要
结直肠癌(colorectal cancer,CRC)是常见的消化道恶性肿瘤,也是导致癌症相关死亡的主要原因之一.表观遗传因素是介导CRC发生、发展的关键因素之一,目前基于组蛋白/DNA甲基化修饰等开发的靶点治疗CRC的临床转化效果不够理想.近年来RNA修饰成为表观遗传领域新的研究前沿与热点,随着大样本多组学联合分析与高通量测序技术在该领域的应用,发现多个RNA修饰相关蛋白在CRC中表现出较好的独立预后价值,并且RNA修饰密切参与CRC的恶性进展、化疗抵抗以及抗肿瘤免疫调节.本文将对RNA修饰在CRC中的最新研究进展进行述评,旨在了解RNA修饰在CRC恶性进展中的作用机制,以期为CRC治疗和预后判断提供新的思路和策略.
Abstract
Colorectal cancer(CRC)is a common malignant tumor of the digestive system and the second leading cause of cancer-related deaths.Epigenesis is one of the key factors that mediate the occur-rence and development of CRC,and the clinical transformation effect of the current target therapy based on histone/DNA methylation modification leaves much to be desired.In recent years,RNA modifications have become a new research frontier and hot spot in the field of epigenetics.With the wide application of large-sample multi-omics analysis and high-throughput sequencing technology in this field,it has been found that several RNA modification-related proteins have good independent prognostic value in CRC,and RNA modi-fications are closely involved in the malignant progression,chemotherapy resistance,and anti-tumor im-mune regulation of CRC.This article reviews the latest research progress of RNA modifications in CRC,ai-ming to understand the mechanism of RNA modifications in the malignant progression of CRC,in hope to provide new ideas and strategies for the treatment and prognosis of CRC.
关键词
结直肠癌/RNA修饰/表观遗传Key words
Colorectal cancer/RNA modifications/Epigenesis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据