The value of serum C-reactive protein,procalcitonin and amyloid protein A in the diagnosis of acute obstructive suppurative cholangitis
Objective To investigate the value of serum C-reactive protein,procalcitonin and am-yloid protein A in the diagnosis of acute obstructive suppurative cholangitis.Methods A total of 91 pa-tients with acute obstructive suppurative cholangitis admitted to our hospital from January 2020 to August 2023 were selected as the research objects(observation group),and 45 healthy people were selected as the control objects(control group).According to the severity of the disease,the patients were divided into cholangitis subgroup,cholangitis combined with sepsis subgroup and cholangitis combined with septic shock subgroup.The serum C-reactive protein level was measured by immune turbidimetric method.The serum procalcitonin level was measured by immunofluorescence method.The amyloid protein A level was meas-ured by latex enhanced immune turbidimetric method.The serum C-reactive protein,procalcitonin and am-yloid protein A levels between the control group and the observation group were analyzed,as well as those between patients without disease severity.????The receiver operating characteristic curve was drawn,the area under the curve was calculated,and the value of serum C-reactive protein,procalcitonin and amyloid protein A alone or in combination in the diagnosis of acute obstructive suppurative cholangitis was analyzed.The t test was used for comparison of measurement data between groups.Results The levels of serum C-reactive protein,procalcitonin and amyloid A in the control group[(1.77±0.81)mg/L,(0.21± 0.07)ng/ml,(5.01±0.78)mg/L]were significantly lower than those in the patients with acute obstruc-tive suppurative cholangitis[(12.91±5.99)mg/L,(2.06±1.04)ng/ml,(192.08±82.64)mg/L,t=12.330,12.330,15.380,P＜0.05].The levels of serum C-reactive protein,procalcitonin and amyloid A in the patients with cholangitis[(7.07±1.36)mg/L,(0.99±0.11)ng/ml,(96.43±11.33)mg/L]were significantly lower than those in the patients with sepsis[(11.57±1.36)mg/L,(1.91± 0.24)ng/ml,(190.54±20.79)mg/L,t=7.287,19.150,21.850,P＜0.05].The levels of serum C-reactive protein,procalcitonin and amyloid A in the patients with sepsis[(11.57±1.36)mg/L,(1.91±0.24)ng/ml,(190.54±20.79)mg/L]were significantly lower than those in the patients with septic shock[(20.08±1.36)mg/L,(3.39±0.24)ng/ml,(292.58±28.22)mg/L,t=10.940,11.300,16.120,P＜0.05].The area under the curve of serum C-reactive protein in the diagnosis of a-cute obstructive suppurative cholangitis with sepsis or septic shock was 0.88,with a sensitivity of 89.00％and a specificity of 98.00％.The area under the curve of procalcitonin in the diagnosis of acute obstructive suppurative cholangitis with sepsis or the area under the curve of the combined detection of serum C-reac-tive protein,procalcitonin and amyloid A in the diagnosis of acute obstructive suppurative cholangitis com-plicated with sepsis or septic shock was 0.95,the sensitivity was 95.00％,and the specificity was 100.00％.Conclusion Serum C-reactive protein,procalcitonin and amyloid protein A in patients with a-cute obstructive suppurative cholangitis significantly increased,and are closely related to the severity of the disease.
Serum C-reactive proteinProcalcitoninAmyloid protein AAcute obstructive suppurative cholangitis
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