Expression of Kinesin family member 20A and programmed cell death 4 in esophageal cancer tissues
Objective To study the expression level of Kinesin family member 20A(KIF20A)and programmed cell death 4(PDCD4)in esophageal cancer tissues,and investigate the relationship between KIF20A and PDCD4 and the clinicopathologic features of esophageal cancer.Methods Cancer tissues and adjacent esophageal tissues of 81 patients with esophageal cancer who were treated in Affiliated Hospital of Guangdong Medical University from May 2021 to November 2023 were collected.The expression of KIF20A and PDCD4 in esophageal cancer tissues and adjacent esophageal'tissues was detected by immunohisto-chemistry,and the relationship between the expression and clinicopathological features of esophageal cancer were evaluated by Chi-square test.Results The expression rate of KIF20A in esophageal cancer tissues was 76.54％(62/81),which was significantly higher than that in adjacent esophageal tissues[23.46％(19/81),x2=45.654,P＜0.01].The expression rate of PDCD4 in esophageal cancer tissues was 43.21％(35/81),which was significantly lower than that in adjacent esophageal tissues[86.42％(70/81),x2=33.158,P＜0.01].The expression level of KIF20A were not significantly correlated with the gender and age of patients with esophageal cancer(respectively,x2=0.002,0.055,P＞0.05).The expression level of KIF20A was significantly correlated with histological differentiation,TNM stage and lymph node metastasis(respectively,x2=7.481,6.067,5.284,P＜0.05).There was no significant cor-relation between the expression level of PDCD4 and the sex,histological differentiation and age of patients with esophageal cancer(respectively,x2=0.036,0.040,0.210,P＞0.05).The expression level of PDCD4 was significantly correlated with TNM stage and lymph node metastasis in patients with esophageal cancer(respectively,x2=5.044,5.620,P＜0.05).Conclusion The expression of KIF20A is high and PDCD is low in esophageal cancer tissues.KIF20A and PDCD4 may play an important role in the occur-rence and development of esophageal cancer.
Immunohistochemical methodEsophageal cancerEndoplasmic Kinesin family member 20AProgrammed cell death 4
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