Prognostic evaluation value of electrocardiogram QRS fragmentation combined with inflammatory factors on patients with myocardial infarction
Objective Exploring the value of electrocardiogram QRS fragmentation wave combined with inflammatory factor detection in evaluating the prognosis of patients with myocardial infarction.Meth-ods 110 patients with myocardial infarction who received treatment at our hospital from September 2020 to September 2022 were selected as the observation group for this study,and 115 individuals who underwent health examinations at our hospital during the same period were selected as the control group for this study.Take venous blood on an empty stomach to detect interleukin(IL)-6,IL-8 and tumor necrosis factor-α(TNF-α)level,conduct comparative analysis;And use ROC curve to analyze IL-6,IL-8,TNF-αDiagnostic efficacy for myocardial infarction;Simultaneously comparing the diagnostic accuracy of differ-ent detection methods for myocardial infarction;Divide myocardial infarction patients into complication group and non complication group based on their prognosis,and compare and analyze IL-6,IL-8,TNF-αdetection result and analyzed;And compare and analyze the coronary angiography results and Lowen grad-ing of the two groups of patients.Results The levels of inflammatory factors IL-6,IL-8,and TNF-α in the observation group of myocardial infarction patients were significantly higher than those in the healthy control group(98.43±34.54,101.62±25.13,321.19±109.66 vs.37.81±19.27,26.39±19.08,161.87 ±84.59,t=16.349,25.359,12.333,respectively,P＜0.05];The diagnostic value of ROC curve a-nalysis for inflammatory factor detection in myocardial infarction is relatively high(AUC=0.852,P＜0.001),and the optimal working points are IL-6=76.82,IL-8=83.55,TNF-α=254.17,sensitivity=0.861,specificity=0.653;Thecombination of electrocardiogram and inflammatory factors was used to di-agnose patients in the observation group.The number of cases/accuracy in the observation group was signif-icantly higher than that in the control group in terms of single detection of electrocardiogram and inflamma-tory factors[(103(93.64％)vs.103(93.64％)and 87(79.09％)vs.73(66.36％),respectivelyx2=9.881,25.568,P＜0.05];In the comparison of coronary angiography results and inflammatory factor lev-els within the observation group,IL-6,IL-8,TNF-α levels were observed in the complication group,The level is significantly higher than that of the non complication group(124.53±34.16,137.62±25.37,409.64±93.28 vs.54.82±11.34,49.26±17.09,201.91±107.72,t=14.672,21.617,10.753,P＜0.05];In the comparison of coronary angiography results and vascular disease rates in patients with different risk stratification,the incidence of single vessel disease in the complication group was significantly lower than that in the non complication group[6(11.54％)vs.37(63.79％),x2=31.443,P＜0.05],the incidence of multiple vessel lesions in patients with complications was significantly higher than that in patients without complications;[(46(88.46％)vs.21(36.21％),x2=31.443,P＜0.05];In the com-parison of the degree of vascular stenosis,the incidence of incomplete occlusion in patients with complica-tions was significantly lower than that in patients without complications[19(36.54％)vs.46(79.31％),x2=20.750,P＜0.05],the incidence of complete occlusion in the complication group was significantly higher than that in the non complication group[33(63.46％)vs.12(20.69％),x2=20.750,P＜0.05];In the comparison of Lowen grading among patients with different risk stratification,the proportion of Lowen Ⅲ patients in the complication group was significantly lower than that in the non complication group[11(21.15％)vs.40(68.97％),x2=25.204,P＜0.05];The proportion of patients with Low Ⅳgrade A and Low Ⅳ grade B in the complication group was significantly higher than that in the non compli-cation group[19(36.54％)vs.10(17.24％)and 22(42.31％)vs.8(13.79％),respectively x2=5.259,9.182,P＜0.05].Conclusion The combination of QRS fragmentation wave and inflammatory factor detection in electrocardiogram has important clinical significance for the diagnosis and prognosis eval-uation of myocardial infarction,the combined detection of the two is helpful for diagnosing the prognosis of myocardial infarction.
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