Effect of combined technology in treating tibial traumatic bone defects and its impact on vascular endothelial growth factor and inflammatory factors in patients
Objective To investigate the effect of Ilizarov bone transfer combined with intramedul-lary guided needle technique in the treatment of traumatic bone defects in the tibia,as well as its impact on vascular endothelial growth factor(VEGF)and inflammatory factors in patients.Methods A total of 70 patients with tibial traumatic bone defects admitted to our hospital from June 2021 to June 2023 were se-lected as the research subjects.According to the surgical methods,the patients were divided into a control group and a combination treatment group.The control group was treated with traditional surgical methods,and the combination treatment group was treated with Ilizarov bone transfer combined with intramedullary guided needle technology.After surgery,the mineralization time,bone healing time,pain visual analogue scale and scaffolding time in the bone extension area of the control group and the combined treatment group were analyzed.The expression levels of the VEGF and inflammatory factors[tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)]at the fracture site were analyzed by enzyme linked immunosorbent as-say(ELISA)and fluorescence quantitative polymerase chain reaction(PCR).The t-test was used for the comparison of measurement data,and the Chi-square test was used for the comparison of count data.Results The mineralization time,bone healing time,and scaffolding time in the bone extension area of the control group[(242.85±17.10),(15.80±1.95),(12.63±1.63)d]were significantly longer than those in the combination treatment group[(202.94±16.21),(12.09±1.70),(9.26±2.08)d,t=0.020,8.479,7.557,P＜0.05].The pain simulation score in the control group(4.40±1.12)was sig-nificantly higher than that in the combined treatment group(2.83±0.92,t=6.417,P＜0.05).The ex-cellent and good treatment rate of 85.71％in the combination treatment group was significantly higher than that of 71.43％in the control group(x2=12.014,P＜0.05).The serum peripheral blood VEGF levels in the control group[(151.67±21.60)ng/L]were significantly lower than those in the combination treat-ment group[(371.65±29.43)ng/L,t=23.340,P＜0.05].The expression level of VEGF mRNA in the bone defect tissue of the control group(1.06±0.14)was significantly lower than that of the combina-tion treatment group(2.45±0.38,t=13.120,P＜0.05).The levels of serum TNF-α and IL-6 in the control group[(66.87±10.59),(84.47±7.62)pg/ml]were significantly lower than those in the combi-nation therapy group[(38.13±4.90),(38.87±9.25)pg/ml,t=9.539,14.730,P＜0.05].The ex-pression level of TNF-α and IL-6 mRNA in bone defect tissue of control group(1.04±0.15,0.93±0.16)was significantly lower than that of the combination therapy group(2.02±0.22,2.21±0.35,t=14.200,12.910,P＜0.05).Conclusion Ilizarov bone transfer combined with intramedullary guided needle tech-nology can significantly improve the microenvironment of tibial traumatic bone defects,and has a good ther-apeutic effect on tibial traumatic bone defects.It can maximize the recovery of patient limb function.
Traumatic bone defect of the tibiaVascular endothelial growth factorInflamma-tory factors
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