Advances in inflammation-related biomarkers for predicting prognosis in patients with colorectal cancer
Colorectal cancer(CRC)is one of the leading causes of cancer-related deaths worldwide.Identif-ying patients at high risk of recurrence and poor prognosis is essential to guide treatment strategies.Inflammation-relat-ed biomarkers such as neutrophil-to-lymphocyte ratio(NLR),lymphocyte-to-C-reactive protein ratio(LCR),platelet-to-lymphocyte ratio(PLR),lymphocyte-to-monocyte ratio(LMR),and C-reactive protein-to-albumin ratio(CAR)have demonstrated the value of predicting the prognosis of a wide range of cancers for clinical applications.In addition,Glasgow Prognostic Score(GPS),Systemic Inflammation Score(SIS),and Prognostic Nutritional Index(PNI),Prog-nostic Immunity and Nutritional Index(PINI),which are scoring systems based on circulating blood counts and albu-min concentrations,have been used to predict cancer prognosis.This article outlines the role of these inflammation-re-lated markers in predicting CRC prognosis,with the aim of informing optimized prognostic prediction and therapeutic decision-making.
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