肠道微生物群与外科重症感染
Gut microbiome and severe surgical infection
张海洋 1莱智勇 2王岩 1程檬 1霍晨达 1白中元 1蔡垚 3李想 2牛志强 2徐钧2
作者信息
- 1. 山西医科大学第一临床医学院,太原 030001
- 2. 山西医科大学第一医院肝胆胰外科及肝脏移植中心,太原 030001
- 3. 山西医科大学医学影像学院,太原 030001
- 折叠
摘要
感染是导致外科重症监护病房中危重患者死亡的主要病因之一.越来越多的证据表明,外科重症患者的感染多来源于肠道中机会致病菌易位.肠道菌群作为人体共生的部分,其代谢产物被人体摄取利用后会影响患者机体的生理病理代谢改变.危重症患者在入住外科重症监护病房期间往往由于外科手术、原发疾病、继发感染以及临床治疗措施的使用,很大程度上引起肠道微生态失调.本文以外科重症患者为焦点,深入回顾外科重症监护病房中患者临床治疗期间肠道微生态的变化特点与肠道微生物影响外科重症感染性疾病发生发展及其预后转归关系的相关研究,作一综述.
Abstract
Infection is one of the leading causes of death in critically ill patients in surgical intensive care u-nits.A growing body of evidence suggests that most infections in surgical intensive care patients originate from translo-cation of opportunistic pathogenic bacteria in the gut.As a symbiotic part of the human body,the intestinal flora,whose metabolites are ingested and utilized by the human body,affects the physiopathological metabolic changes in the patient's organism.Critically ill patients often suffer from intestinal microecological dysbiosis to a large extent during their stay in the surgical intensive care unit due to surgical procedures,primary diseases,secondary infections and the use of clinical therapeutic measures.In this article,we focus on critically ill surgical patients and review in depth the characteristics of changes in gut microecology during clinical treatment of patients in surgical intensive care units in re-lation to the influence of gut microbes on the development of infectious diseases in surgical intensive care and their prognostic prognosis and regression.
关键词
感染/外科手术/危重病/胃肠道微生物组Key words
Infections/Surgical procedures/Critical Illness/Gastrointestinal microbiome引用本文复制引用
基金项目
山西省自然科学基金(202103021224408)
出版年
2024
NETL
NSTL
万方数据