Infection is one of the leading causes of death in critically ill patients in surgical intensive care u-nits.A growing body of evidence suggests that most infections in surgical intensive care patients originate from translo-cation of opportunistic pathogenic bacteria in the gut.As a symbiotic part of the human body,the intestinal flora,whose metabolites are ingested and utilized by the human body,affects the physiopathological metabolic changes in the patient's organism.Critically ill patients often suffer from intestinal microecological dysbiosis to a large extent during their stay in the surgical intensive care unit due to surgical procedures,primary diseases,secondary infections and the use of clinical therapeutic measures.In this article,we focus on critically ill surgical patients and review in depth the characteristics of changes in gut microecology during clinical treatment of patients in surgical intensive care units in re-lation to the influence of gut microbes on the development of infectious diseases in surgical intensive care and their prognostic prognosis and regression.