Analysis of clinicopathological characteristics and dominant components of mixed hepatocellular carcinoma
Objective The proportion cutoff value of hepatocellular carcinoma(HCC)associated with prognosis and intrahepatic cholangiocarcinoma(ICC)components in mixed hepatocellular carcinoma combined hepatocellular-cholangiocarcinoma(cHCC-CC)was analyzed to provide a theoretical basis for tumor treatment.Methods The clinical pathology and follow-up data of 46 cHCC-CC patients from Janu-ary 2015 to January 2021,and 30 of HCC patients and ICC patients during the same period were selected for the clinical and prognostic characteristics of cHCC-CC,HCC and HCC and ICC,and the best cut-off value of cHCC-CC was analyzed using X-tile software.Results The mean age of onset of cHCC-CC pa-tients was less than that in ICC patients[(54.33±12.55)years vs.(61.20±11.21)years,t=-2.433,P＜0.05].Serum alpha-fetoprotein(AFP)level in cHCC-CC patients was higher than that in ICC patients[30.43％(14/46)vs.0.00％(0/0),x2=11.190,P＜0.05],and the positive rate of hepatitis B virus(HBV)in cHCC-CC patients was higher than that in ICC patients[80.43％(37/46)vs.36.66％(11/30),x2=16.948,P＜0.05].However,the rate of lymph node metastasis in cHCC-CC patients was lower than that in ICC patients[10.86％(5/46)vs.36.66％(11/30),x2=7.270,P＜0.05].The pro-portion of 5 cm in cHCC-CC patients was significantly higher than in HCC pateints[71.73％(33/46)vs.46.66％(14/30),x2=4.837,P＜0.05].The proportion of histologically poorly differentiated in HCC-CC patients was significantly lower than in HCC patents[67.39％(31/46)vs.90.00％(27/30),x2=5.135,P＜0.05].The overall postoperative survival rate of patients in the cHCC-CC group was sig-nificantly higher than that in the ICC group[69.56％(32/46)vs.26.67％(8/30),x2=8.733,P＜0.05].The X-tile software analysis showed that the optimal cut-off of ICC component in cHCC was 15％,and the overall survival of 15％ICC component was significantly better than that of 3％-14％ICC compo-nent[75.67％(28/37)vs.44.44％(4/9),x2=5.654,P＜0.05].Conclusion The proportion of HCC and ICC components in cHCC-CC is closely related to the prognosis.
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