肿瘤外泌体在脑转移瘤微环境中作用机制的研究进展
Research progress in the mechanisms of tumor-derived extracellular vesicles in the brain metastasis microenvi-ronment
朱凯涛 1李世伟 1张善义1
作者信息
- 1. 中山大学孙逸仙纪念医院神经外科,广州 510120
- 折叠
摘要
造成恶性肿瘤患者死亡的主要原因之一是肿瘤脑转移,以肺癌、乳腺癌和黑色素瘤的脑转移最为常见.脑转移瘤的发生常意味着患者生存期的缩短以及不良预后,其治疗方法包括手术、放射治疗、化学治疗、免疫治疗以及靶向治疗,但脑转移瘤患者的生存期只有约12个月甚至更少,因此进一步研究肿瘤脑转移发生的机制以及开发新的治疗策略显得尤为紧迫.研究表明,原发部位肿瘤可以通过分泌外泌体的方式运输核酸、脂质以及蛋白质等生物信息分子作用于脑转移瘤微环境,影响脑转移瘤微环境中的细胞及细胞外成分,从而促进肿瘤脑转移的发生.本综述主要介绍外泌体与脑转移瘤发生的关系以及在开发脑转移瘤治疗新策略中的应用前景.
Abstract
One of the leading causes of mortality in malignant tumor patients is brain metastasis,with lung cancer,breast cancer,and melanoma being the most common culprits.The occurrence of brain metastases often signi-fies shortened survival and poor prognosis for patients.Treatment options for brain metastasis include surgery,radiation therapy,chemotherapy,immunotherapy,and targeted therapy.However,despite these interventions,the average sur-vival of patients with brain metastasis remains around 12 months or less.Therefore,further investigation of the mecha-nisms underlying tumor brain metastasis and the development of novel therapeutic strategies are urgently needed.Re-cent studies have revealed the crucial role of the brain metastasis microenvironment in tumor brain metastasis.Extracel-lular vesicles play a key role in intercellular communication within this microenvironment.Primary tumors can release extracellular vesicles(EVs)to influence cellular and extracellular components within the brain metastasis microenviron-ment,thereby promoting the progression of brain metastasis.This review primarily focuses on the relationship between EVs and the development of brain metastasis,as well as the potential applications of EVs in the development of novel treatment strategies for brain metastasis.
关键词
脑转移瘤/外泌体/肿瘤微环境/血脑屏障Key words
Brain metastasis/Extracellular vesicles/Tumor microenvironment/Blood-brain barrier引用本文复制引用
基金项目
广东省自然科学基金(2018A0303130193)
广东省自然科学基金(2022A1515012393)
广东省医学科研面上项目(A2016072)
广州市重点领域研发计划(2023B03J0079)
逸仙启航基金面上项目(YXQH201803)
出版年
2024
NETL
NSTL
万方数据