Communication and immune regulation of tumor-derived exosomes in the lung cancer microenvironment
Lung cancer is the leading cause of cancer deaths globally,and despite current advances in the ear-ly diagnosis and treatment of lung cancer,overall survival rates remain low.Lung cancer development is a multifactori-al outcome,including interactions between lung cancer cells and their cellular microenvironment(immune cells).Exo-somes,as a kind of extracellular vesicles,play an important role in regulating tumor growth,promoting vascular prolif-eration,tumor invasion and metastasis.Tumor-derived exosomes(TEXs)contain a variety of tumor-associated macro-molecules and may promote tumor proliferation by affecting immune cell function.Therefore,it is of great significance to understand the communication and immunomodulatory role of TEXs in the microenvironment of lung cancer.In this paper,we review the regulatory effects of TEXs on lung cancer immune cells in light of current research progress.
ExosomeLung cancerImmune regulationCellular communication
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