Regulation of long non-coding RNAs on myocardial ischemia/reperfusion injury
Myocardial ischemia-reperfusion injury(MIRI)poses a major challenge for perioperative cardiac surgery,involving multiple cell types and complex molecular mechanisms.Long non-coding RNAs(lncRNAs)have shown unique potential in the treatment and prognostic diagnosis of heart diseases,particularly myocardial infarction.This review aims to explore the role of lncRNAs in MIRI and their potential therapeutic applications.Studies have indi-cated that specific lncRNAs,such as H19,MALAT1,HCP5,and NEAT1,can mitigate MIRI and promote cardiac function recovery by regulating microRNA(miRNA)expression and participating in various signaling pathways.Exo-somes,as effective carriers for delivering lncRNAs,have shown great potential in myocardial infarction treatment by regulating the survival and death of myocardial cells through specific lncRNA/miRNA axes,providing new therapeutic strategies.Furthermore,changes in lncRNA expression levels are closely associated with the diagnosis and prognosis of acute myocardial infarction(AMI),surpassing the diagnostic value of traditional biomarkers.Therefore,a deep under-standing of the role of lncRNAs in the cardiac protection mechanism mediated by exosomes is of significant importance for the development of novel myocardial infarction treatments.
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