长链非编码RNA对心肌缺血再灌注损伤的调控研究进展
Regulation of long non-coding RNAs on myocardial ischemia/reperfusion injury
谢润珊 1李依静 2吴多志 3李支笑2
作者信息
- 1. 江汉大学,武汉 430056
- 2. 华中科技大学同济医学院附属同济医院麻醉科,湖北省老年麻醉与围术期脑健康重点实验室,武汉市老年麻醉临床研究中心,武汉 430030
- 3. 海南省人民医院麻醉科,海口 570311
- 折叠
摘要
心肌缺血再灌注损伤(MIRI)是围术期心脏手术的一大挑战,涉及多种细胞类型和复杂的分子机制.长链非编码RNA(lncRNA)在心脏病,特别是心肌梗死的诊断、治疗和预后评估中显示出独特的潜力.本文旨在探讨lncRNA在MIRI中的作用及其潜在的治疗应用.研究表明,特异性lncRNA,如H19、MALAT1、HCP5和NEAT1,可以通过调节微小RNA(miRNA)表达参与各种信号通路来减轻MIRI并促进心功能恢复.外泌体作为递送lncRNAs的有效载体,通过特定的lncRNA/miRNA轴调节心肌细胞的存活和死亡,在心肌梗死治疗中显示出巨大的潜力,提供新的治疗策略.此外,lncRNA表达水平的变化与急性心肌梗死(AMI)的诊断和预后评估密切相关,超过传统生物标志物的诊断价值.因此,深入了解lncRNA在外泌体介导的心脏保护机制中的作用,对开发新型心肌梗死治疗方法具有重要意义.
Abstract
Myocardial ischemia-reperfusion injury(MIRI)poses a major challenge for perioperative cardiac surgery,involving multiple cell types and complex molecular mechanisms.Long non-coding RNAs(lncRNAs)have shown unique potential in the treatment and prognostic diagnosis of heart diseases,particularly myocardial infarction.This review aims to explore the role of lncRNAs in MIRI and their potential therapeutic applications.Studies have indi-cated that specific lncRNAs,such as H19,MALAT1,HCP5,and NEAT1,can mitigate MIRI and promote cardiac function recovery by regulating microRNA(miRNA)expression and participating in various signaling pathways.Exo-somes,as effective carriers for delivering lncRNAs,have shown great potential in myocardial infarction treatment by regulating the survival and death of myocardial cells through specific lncRNA/miRNA axes,providing new therapeutic strategies.Furthermore,changes in lncRNA expression levels are closely associated with the diagnosis and prognosis of acute myocardial infarction(AMI),surpassing the diagnostic value of traditional biomarkers.Therefore,a deep under-standing of the role of lncRNAs in the cardiac protection mechanism mediated by exosomes is of significant importance for the development of novel myocardial infarction treatments.
关键词
心肌缺血再灌注损伤/长链非编码RNAsKey words
Myocardial ischemia-reperfusion injury/Long non-coding RNAs引用本文复制引用
基金项目
海南省重点研发计划(ZDYF2021SHFZ087)
出版年
2024
NETL
NSTL
万方数据