Progress in studies related to the induction of mitophagy by nuclear respiratory factor 1
Mitophagy is a selective autophagy that occurs at the mitochondrial level,removing toxic peroxida-tion products and damaged mitochondria,and maintaining the healthy quality of intracellular mitochondria.Successful transcription of antioxidant proteins is an essential factor in the development of mitophagy.Therefore,it is crucial to i-dentify and intensively study the transcription factors associated with mitophagy.Nuclear respiratory factor 1(NRF1)is a transcription factor at the nuclear level that transmits to the nucleus to transcribe a variety of protein molecules related to the antioxidant system,and the essential role of NRF1 in mitophagy has emerged as a new research topic.However,the specific mechanisms involved are still not unanimous and there are many unknown issues,which greatly limit the exploration of NRF1 regulation of mitophagy.In this paper,we briefly review the research progress of NRF1 and mito-phagy,and highlight and explore the relationship between them to provide new insights for future research direction and clinical translation.
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