Differential gene expression and enrichment analysis in asymptomatic gliomas
Objective To find a new target for the comprehensive diagnosis and treatment of glio-mas,we analyzed the differentially expressed genes and related enrichment pathways of asymptomatic world health organization(WHO)grade 2 gliomas.Methods In total,27 patients aged(42.1±11.2)years old with WHO grade 2 glioma who received surgical treatment in Department of Neurosurgery of the First Affiliated Hospital of Zhengzhou University from January 2018 to December 2019 were selected for this study.The clinical follow-up data and sequencing data were obtained and divided into asymptomatic group(9 cases)and symptomatic group(18 cases).The difference in gene expression between the two groups was analyzed by R language software.The Metascape website enrichment analysis was done to find the rele-vant enrichment pathways.Results In 27 WHO grade 2 glioma patients,127 differentially expressed genes were screened,including 52 up-regulated genes and 75 down-regulated genes,which were enriched in biological pathways such as acute inflammatory response,blood circulation,sulfur compound binding,and neuroactive ligand receptor interaction.Conclusion Asymptomatic WHO grade 2 gliomas exhibit spe-cific gene expression differences and related enrichment pathways.
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