Correlation between the chemotherapy response in patients with non-small cell lung cancer and solu-ble intercellular adhesion molecule-1,P-glycoprotein,p53 and CT perfusion imaging parameters
Objective To investigate the correlation between soluble intercellular adhesion mole-cule-1(sICAM-1),P-glycoprotein(P-gp),tumor suppressor gene p53,and CT perfusion imaging parame-ters with the chemotherapy response in patients with non-small cell lung cancer(NSCLC).Methods A total of 86 patients with advanced NSCLC treated in the Department of Cardiothoracic and Vascular Surgery in Ninth Clinical Medical College of Guangxi Medical University from January 2020 to January 2023 were enrolled in this study.All patients received platinum-based chemotherapy.Based on the chemotherapy re-sponse,the patients were divided into two groups:effective chemotherapy group(n=37)and ineffective chemotherapy group(n=49).The differences in clinical data,sICAM-1,P-gp,p53,and CT perfusion im-aging parameters were analyzed between the two groups.For continuous variables,the t-test,ANOVA,or non-parametric test was used to analyze the differences between groups.For categorical variables,the Chi-square test was used to analyze the differences between groups.Results Totally,30 patients in the inef-fective chemotherapy group were at TNM stage Ⅳ,which was more than that in the effective chemotherapy group(n=16)(x2=4.455,P<0.05).There were 27 patients with poorly differentiated tumors in the in-effective chemotherapy group,which were more than in the effective chemotherapy group(n=13)(x2=4.982,P<0.05).The peripheral blood sICAM-1 level before chemotherapy in the ineffective chemothera-py group was significantly higher(910.02±98.70 ng/ml)than in the effective chemotherapy group(Z=-6.654,P<0.001).The positive rate of tissue P-gp and p53 before chemotherapy in the ineffective chemotherapy group were 70.21%and 55.32%,respectively,which was significantly higher than that in the effective chemotherapy group(P-gp:x2=5.112,P<0.05;p53:x2=6.392,P<0.05).The blood flow(BF)before chemotherapy in the ineffective chemotherapy group(65.56±11.02)ml/(100 ml·min)was significantly greater than in the effective chemotherapy group(t=9.713,P<0.01).For patients at TNM stage Ⅳ,the levels of sICAM-1,P-gp,and p53 before chemotherapy were significantly higher than those in patients at TNM stage Ⅲ B[sICAM-1:(875.00±86.65)ng/ml,Z=-4.650,P<0.001;P-gp:73.91%,x2=8.748,P<0.01;p53:56.52%,x2=7.351,P<0.01].For patients with poorly differentiated tumors,the levels of sICAM-1,P-gp,and p53 before chemotherapy were significantly higher than those in patients with moderate-to well-differentiated tumors(sICAM-1:872.99±88.34 ng/ml,Z=4.243,P<0.001;P-gp:87.50%,x2=24.637,P<0.001;p53:57.50%,x2=6.394,P<0.05).The BF before chemotherapy in patients at TNM stage Ⅳ(70.89±9.17)ml/(100 ml·min)was signifi-cantly lower than that in patients at TNM stage ⅢB(t=7.368,P<0.001).The BF before chemotherapy in patients with poorly differentiated tumors(71.75±9.34)ml/(100 ml·min)was significantly lower than that in patients with moderate-to well-differentiated tumors(t=-6.366,P<0.001).Conclusion The levels of sICAM-1,P-gp,p53,and the CT perfusion imaging parameter BF are associated with the chemo-therapy response,TNM staging,and the degree of differentiation in patients with NSCLC.