Analysis of risk factors for chemotherapy-induced nausea and vomiting in lung cancer patients and construction of a nomogram prediction model
Objective To analyze the risk factors of chemotherapy-induced nausea and vomiting(CINV)in lung cancer patients using univariate and multivariate logistic regression,and to construct and val-idate a nomogram prediction model.Methods Clinical data of lung cancer patients from the Department of Oncology,the First Affiliated Hospital of Zhengzhou University,from October 2021 to June 2022 were col-lected.A total of 950 patients meeting the inclusion criteria were selected.According to a random number ta-ble,patients were divided into a training cohort(n=665)and a validation cohort(n=285)at a ratio of 7∶3.After conducting univariate and multivariate logistic regression analyses on the training cohort,independent risk factors for CINV were screened,and a nomogram model was established.The accuracy and consistency of the nomogram prediction model were evaluated using the area under the receiver operating characteristic curve(AUC)and the Hosmer-Lemeshow(HL)test.Results A total of 6 independent risk factors for CINV in non-smoking lung cancer patients were selected through univariate and multivariate logistic regression.A nomogram predicting CINV risk was constructed,with AUCs of 0.887[95％confidence interval(CI):0.861-0.891]and 0.823(95％CI:0.806-0.831)for the training and internal validation cohorts,respec-tively.The HL goodness-of-fit test showed good consistency between predicted and actual observations in both the training and internal validation cohorts(x2=7.89,P＞0.05 for the training cohort;x2=5.55,P＞0.05 for the internal validation cohort).Conclusion Non-smoking status,history of motion sickness,use of plat-inum-based chemotherapy drugs,absence of chemotherapy history,use of opioid analgesics,and sleep dura-tion less than 7 h are risk factors for CINV in lung cancer patients.A nomogram prediction model for CINV in lung cancer patients based on these factors demonstrates good accuracy and consistency.
Lung cancerChemotherapyNausea and vomitingNomogram
NETL
NSTL
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