Research progress in C-C chemokine ligand 5 and chemokine C-C motif receptor 5 in gastric cancer
Gastric cancer is a common malignant tumor with poor prognosis and 5-year survival rate of less than 50％.Its pathogenesis is still unclear.The existence of tumor microenvironment(TME)promoted the proliferation,migration and immune escape ability of tumor cells,thus promoting the occurrence and development of tumors.C-C chemokine ligand 5(CCL5)is a chemokine in the TME.The biological axis composed of CCL5 and its receptor,che-mokine C-C motif receptor 5(CCR5),plays an active role in the recruitment of tumor-associated immunosuppressive cells,and has been shown to be closely related to the growth and metastasis of gastric cancer cells.Therefore,the CCL5/CCR5 biological axis is expected to provide more evidence and guidance in the diagnosis,treatment and progno-sis of gastric cancer.This article reviews the role of CCL5/CCR5 biological axis in the occurrence and development of gastric cancer and the progress of related targeted therapy.
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