腺泡细胞死亡模式在急性胰腺炎中的研究进展
Research progress in acinar cell death model in acute pancreatitis
田军 1徐萍1
作者信息
- 1. 上海交通大学医学院附属松江医院(筹)消化内科,上海 201600
- 折叠
摘要
急性胰腺炎(AP)是一种累及胰腺局部和全身的炎性疾病,通常呈自限性,但仍有20％的患者易发展为重症急性胰腺炎(SAP),从而导致全身炎症反应综合征和累及肺、肾、肝和心脏等多器官功能障碍和衰竭.SAP患者易出现糖尿病、胰腺外分泌功能障碍、慢性胰腺炎等远期并发症,严重影响生活质量.胰腺腺泡细胞损伤与死亡是AP早期发生的主要病理生理特点,目前研究表明不同细胞死亡模式在AP的发生发展中发挥重要作用,本文就此展开综述,为AP的发病机制和治疗提供新的认识和调控靶点.
Abstract
Acute pancreatitis(AP)is a disease of inflammation that accumulates locally and throughout the pancreas and is usually self-limiting,but still predisposes 20％of patients to develop severe acute pancreatitis(SAP),which results in systemic inflammatory response syndrome and cumulative multi-organ dysfunction and failure of the lungs,kidneys,liver,and heart.SAP patients are prone to diabetes,pancreatic exocrine dysfunction,chronic pancre-atitis and other long-term complications,which seriously affect the quality of life.Pancreatic acinal cell injury and death are the main pathophysiological features of the early development of AP.Current studies have shown that different cell death modes play an important role in the occurrence and development of AP.This review provides new under-standing and regulatory targets for the pathogenesis and treatment of AP.
关键词
急性胰腺炎/腺泡细胞/死亡Key words
Acute pancreatitis/Acinar cells/Death引用本文复制引用
基金项目
上海市松江区科技攻关计划(22SJKJGG81)
上海交通大学医学院附属松江医院(筹)优秀青年人才项目(QNRC004)
出版年
2024
NETL
NSTL
万方数据