Research progress in acinar cell death model in acute pancreatitis
Acute pancreatitis(AP)is a disease of inflammation that accumulates locally and throughout the pancreas and is usually self-limiting,but still predisposes 20％of patients to develop severe acute pancreatitis(SAP),which results in systemic inflammatory response syndrome and cumulative multi-organ dysfunction and failure of the lungs,kidneys,liver,and heart.SAP patients are prone to diabetes,pancreatic exocrine dysfunction,chronic pancre-atitis and other long-term complications,which seriously affect the quality of life.Pancreatic acinal cell injury and death are the main pathophysiological features of the early development of AP.Current studies have shown that different cell death modes play an important role in the occurrence and development of AP.This review provides new under-standing and regulatory targets for the pathogenesis and treatment of AP.
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