Effects of intravascular microcatheter intervention for cerebral aneurysms on cognition and stress
Objective To investigate the effects of intravascular microcatheter intervention for cer-ebral aneurysms on cognition and stress.Methods A total of 64 patients with cerebral aneurysms in our hospital from July 2018 toJuly2023 were selected as the study objects,and were divided into microscope clamp group(32 cases)and intravascular microcatheter group(32 cases)according to the surgical proce-dures.Patients in the control group were treated with microscope clamp,and those in the observation group were treated with intravascular microcatheter interventional therapy.The perioperative changes of related in-dexes in the two groups were analyzed,and the postoperative Hunt-Hess grade and complication rate one month after surgery were analyzed.National institutes of health stroke scale(NIHSS)was used to evaluate the changes of nerve function in the microscope clamp group and the intravascular microcatheter group be-fore and one month after surgery,respectively.Montreal cognitive assessment(MoCA)scale and brief mental state assessment(MMSE)scale were used to evaluate cognitive function before and one month after surgery,respectively.The changes of serum immunofunction indexes such as immunoglobulin IgA and IgG,and inflammatory indexes such as matrix metalloproteinase(MMP)-9,hypoxia inducible factor(HIF)-1α,monocyte chemoattractant protein(MCP)-1 and leukocyte interleukin(IL)-10 in the two groups were ana-lyzed before and 1 month after surgery.T test was used to compare measurement data between groups.Results The perioperative time and hospital stay in the microscope clamp group[(2.86±0.43)h,(16.59±2.79)d]were significantly longer than those in the intravascular microcatheter group[(1.98±0.35)h,(10.47±2.26)d,t=9.649,9.066,P＜0.05].The incidence of complications 1 month after operation in the intravascular microcatheter group[6.25％(2/32)]was significantly lower than that in the microscope clamp group[15.63％(5/32),X2=5.124,P＜0.05].Serum immunoglobulin IgA and IgG levels in intravascular microcatheter group[(2.31±0.11),(11.47±1.54)g/L]1 month after surgery were significantly higher than those in microscope clamp group 1 month after surgery[(1.97±0.11),(9.28±2.14)g/L,t=12.500,4.683,P＜0.05].Serum tumor necrosis factor-α(TNF-α)and MCP-1 levels in intravascular microcatheter group 1 month after surgery[(276.78±25.99,(17.94±2.80)pg/ml]were significantly lower than those in the microscope clamp group one month after surgery[(375.41±25.01),(21.34±2.40)pg/ml,t=15.470,5.216,P＜0.05].MoCA and MMSE scores in the intravascular microcatheter group 1 month after surgery[(28.28±2.08),(27.84±1.80)points]were significantly higher than those in the microscope clamp group[(24.56±1.27),(23.53±4.31)points,t=8.627,5.223,P＜0.05].The NIHSS score in the intravascular microcatheter group 1 month after sur-gery[(9.46±1.16)points]was significantly higher than that in the microscope clamp group 1 month after surgery[(7.66±1.12)points,t=6.336,P＜0.05].Conclusion Intravascular microcatheter interven-tion for cerebral aneurysm can effectively improve perioperative indexes,improve immune function,reduce inflammatory response,and improve neurological function and cognitive ability of patients.
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