Effect of foramen ovale occlusion on serum homocysteine level in patients with patent foramen ovale complicated with cryptogenic stroke
Objective To explore the effect of foramen ovale occlusion on homocysteine(Hcy)levels in patients with patent foramen ovale(PFO)complicated with cryptogenic stroke(CS).Methods The 981 patients with CS in Zhengzhou Central Hospital from October 2018 to December 2022 were retro-spectively analyzed and divided into 0,1,2,and 3 groups according to the right-to-left shunt volume of the foaming experimental heart.The Hcy levels were compared among the four groups.For those with CS com-bined with medium-large right-to-left shunt,the patients were divided into blocked and non-blocked groups according to their wishes,and the serum Hey reduction values were compared after 6 months.In the blocked group,Hcy levels were measured in the right atrium and left atrium before blocking,and in the right atrium and femoral artery after blocking,and the differences were compared.In the blocked group,the foaming test was repeated 6 months after the operation,and the results were classified as no residual shunt,mild residual shunt,and moderate to severe residual shunt,and the differences in Hey levels were compared after 6 months.Normally distributed quantitative data were expressed as the mean plus or minus the standard deviation((x)±s),and group comparisons were made using parametric tests.Non-normally dis-tributed quantitative data were expressed as M(Q1,Q3),and group comparisons were made using non-par-ametric tests.Results The serum Hcy level in CS patients with PFO(grade Ⅱ:17 μmol/L;grade Ⅲ:21 μmol/L)was significantly higher than that in patients without PFO(grade 0:14.7 μmol/L)(P<0.05).The decrease of blood Hcy in PFO operation group(5 μmol/L)was significantly higher than that in non-operation group(3.35 μmol/L)(P<0.05).Conclusion The presence of PFO may elevate the ser-um level of Hcy,and PFO occlusion may reduce the level of Hcy in CS patients.