Relationship between serum indicators,imaging manifestations,and clinical staging in patients with giant cell tumor of bone
Objective To investigate the relationship between serum type Ⅰ collagen cross-linked N-terminal peptide(NTx),vascular endothelial growth factor(VEGF),imaging findings and clinicopatho-logical staging in patients with giant cell tumor of bone.Methods From January 2018 to December 2022,73 patients with giant cell tumor of bone in Yantai Mountain Hospital were selected as the case group,and 80 healthy volunteers were selected as the control group.Serum NTx and VEGF levels were compared be-tween the two groups.At the same time,patients in the case group received computed tomography(CT)and magnetic resonance imaging(MRI)examinations.According to the staging characteristics of tumor pathology,the differences in serum NTx,VEGF levels and imaging features of patients with giant cell tumor of bone were stratified and compared.The t-test was used for the comparison of serum NTx and VEGF lev-els.Count data were described by rate(％)and the comparison hypothesis was tested by x2 test,with P＜0.05 as the difference was statistically significant Results The serum levels of NTx and VEGF[(28.61±5.93)nmol BCE/L and(411.3±93.5)pg/ml]in the case group were significantly higher than those in the control group[(18.44±3.70)nmol BCE/L and(163.9±34.0)pg/ml,t=12.844,t=22.123,P＜0.05].In 73 patients with giant cell tumors of bone,according to Jaffe staging criteria,there were 11 cases in stage Ⅰ,32 cases in stage Ⅱ,and 30 cases in stage Ⅲ.The serum NTx and VEGF[(24.01±5.11)nmol BCE/L and(377.8±88.4)pg/ml]levels in patients with stage Ⅰ+stage Ⅱ giant cell tumors were significant-ly lower than those in stage Ⅲ patients[(35.20±5.67)nmol BCE/L and(459.3±75.0)pg/ml,t=-8.799,-4.118,P＜0.05].Conclusion The serum levels of NTx and VEGF in patients with giant cell tumor of bone are significantly higher than those in the normal population.There are significant differences in NTx,VEGF,and imaging characteristics among patients with giant cell tumor of bone at different pathologi-cal stages,which is of great value in determining the patient's condition.
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