New mechanism of ferroptosis involved in acute kidney injury
Acute kidney injury(AKI)is a common and severe clinical renal syndrome caused by various phys-iological and pathological factors,which is mainly characterized by acute transient renal function reduction.Its morbid-ity and mortality are high,and effective clinical treatment strategies are limited.There is increasing evidence that fer-roptosis,as an iron-dependent and non-apoptotic regulated cell death caused by lipid peroxidation,is characterized by iron overload,reactive oxygen species accumulation and lipid peroxidation.It plays an important role in AKI caused by rhabdomyolysis,sepsis,ischemia reperfusion injury and the use of nephrotoxic drugs.This paper aims to summarize and extend the inducing mechanism and the defense mechanism of ferroptosis as well as its pathways involved in AKI,so as to provide a theoretical basis for subsequent relevant studies.
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