Current status and perspectives of lipid metabolic reprogramming in clear cell renal cell carcinoma
Lipid metabolic reprogramming plays an important role in the biological progression of clear cell re-nal cell carcinoma(ccRCC),which provides the necessary material basis for tumor cells and plays an important role in tumor development.With the application of technologies such as lipidomics,metabolomics and high-throughput se-quencing in scientific research,scientists have gained a deeper understanding of the lipid metabolism characteristics and regulatory mechanisms of ccRCC.It is now found that most tumors tend to use fatty acid catabolism to provide en-ergy,whereas ccRCC relies more on lipids accumulated in the cytoplasm to build the cell membrane skeleton and medi-ates intercellular signaling.Therefore,abnormal lipid metabolism is considered an important biological hallmark of ccRCC.This article focuses on the relationship between obesity,dyslipidemia,lipid metabolism-related enzymes and key regulatory molecules and the progression of ccRCC to provide new strategies for the treatment of ccRCC.
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