Advances in mesenchymal stem cell-derived extracellular vesicles in the treatment of liver diseases
Mesenchymal stem cells(MSCs),a common cell source in stem cell therapy,promote liver regen-eration and repair liver damage through migration to the liver,liver-derived differentiation,and paracrine mechanisms.Extracellular vesicles(EVs)are a natural carrier secreted by almost all cells,mainly acting as maintaining intercellular communication.Their contents and functions are often similar to those of parental cells.Due to the advantages of EVs,there have been numerous studies of MSCs-EVs for treating liver diseases.This paper summarizes the action mecha-nism and clinical application of the cell-free therapy of MSCs-EVs in nonalcoholic fatty liver diseases,liver fibrosis,liver cancer,and liver regeneration.It provides new ideas for the treatment of liver diseases.
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