Progress of anti-tuberculosis drug delivery system actively targeting macrophages
Tuberculosis is one of the deadliest chronic diseases worldwide caused by Mycobacterium tuberculosis.As a facultative intracellular bacterium that mainly parasitizes macrophages,Mycobacterium tuberculosis is difficult to kill by maintaining a latent state in the host through immune evasion and immunosuppression of macrophages.There-fore,killing and inhibiting Mycobacterium tuberculosis in macrophages is important to ensure the cure of tuberculosis.Traditional anti-tuberculosis drug therapy has the disadvantages of low bioavailability,long medication cycle,and high toxicity.Antituberculous drug delivery systems that actively target macrophages can increase phagocytosis of drug-load-ed systems by macrophages by producing ligand-receptor interactions with macrophages,thereby achieving effective bactericidal concentrations within macrophages.The authors will review the research progress of active targeting of anti-tuberculosis drug delivery systems in macrophages against the background of the pathogenic mechanism of Mycobacteri-um tuberculosis and its immune evasion and immunosuppression of macrophages.
TuberculosisMacrophagesActive targetingDrug delivery system
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