骨科基础研究的现状与展望
The present situation and prospect of basic research in orthopedics
杨操 1宋雨1
作者信息
- 1. 华中科技大学同济医学院附属协和医院骨科,武汉 430022
- 折叠
摘要
肌肉骨骼系统疾病日渐成为人群慢性致残的重要病因.尽管药物、康复及手术治疗可缓解疼痛、重建肢体功能进而改善患者生活质量,但尚无延缓或阻断疾病进展的早期预防和治疗手段.近年来,基础实验研究的不断深入为探讨肌肉骨骼系统疾病的发病机制及潜在干预方法奠定了坚实的理论基础,有望为早期诊断和精准治疗提供新方法.同时,现阶段基础研究多基于成熟的疾病模型和实验方法,研究模式较为传统和统一,仍不能实现高效的临床转化应用.本文将从椎间盘退变、骨关节炎、骨质疏松、干细胞及骨生物材料几个方面依次对肌肉骨骼系统疾病基础实验研究现状及未来潜在研究方向进行讨论和展望.
Abstract
Musculoskeletal disorders are increasingly becoming important causes of chronic disabil-ity in the population.Although the patients'quality of life could be improved by pain alleviation and limb function reconstruction through drug administration,rehabilitation,and surgical treatment,there is no early prevention and treatment method to delay or block disease progression.In recent years,the continuous deepening of basic experimental research has laid a solid theoretical foundation for exploring the pathogene-sis and potential intervention methods of musculoskeletal disorders,which is expected to provide new meth-ods for early diagnosis and precise treatment.However,due to the traditional and unified nature of current basic experimental research plans and research models,efficient clinical translation applications cannot be achieved yet.This article will discuss and prospect the present situation and potential future directions of basic experimental research on musculoskeletal disorders from several aspects,including intervertebral disc degeneration,osteoarthritis,osteoporosis,stem cells,and biomaterials.
关键词
肌肉骨骼系统疾病/椎间盘退变/骨关节炎/骨质疏松/干细胞/生物材料Key words
Musculoskeletal disorders/Intervertebral disc degeneration/Osteoarthritis/Osteoporosis/Stem cell/Biomaterials引用本文复制引用
基金项目
国家自然科学基金(82130072)
国家自然科学基金(82072505)
湖北省自然科学基金(2023AFB532)
出版年
2024
NETL
NSTL
万方数据