Effects of interventional embolization on perioperative indexes,postoperative complications,serum hypersensitive C-reactive protein and superoxide dismutase levels in patients with hemorrhagic shock caused by pelvic fracture
Objective To investigate the effect of interventional embolization in patients with hem-orrhagic shock caused by pelvic fracture.Methods From February 2021 to May 2023,62 patients with hemorrhagic shock caused by pelvic fracture were selected as the research objects.They were included strictly based on inclusion and exclusion criteria,and were divided into control group(n=30,conventional surgical treatment)and observation group(n=32,interventional embolization)according to treatment methods.Perioperative indexes,coagulation function indexes[fibrinogen(FIB),prothrombin time(PT),thrombin time(TT),activated partial prothrombin time(APTT)],inflammatory factor levels[serum hypersensitive C-reactive protein(hs-CRP),tumor necrosis fact-α(TNF-α)],oxidative stress degree[ser-um superoxide dismutase(SOD),malondialdehyde(MDA)],incidence of postoperative complications were compared between two groups.T test was used for measurement data,and x2 test was used for counting data.Results The amount of intraoperative blood transfusion and infusion in the observation group[(1 214.33±325.47),(2 576.74±372.19)ml]was less than that in the control group[(2 348.68±430.92),(4 450.53±413.82)ml,t=11.743,18.768,P＜0.05],and the correction time of shock[(2.78±0.38)h]was shorter than that in the control group[(10.96±2.85)h,t=49.443,P＜0.05].After treatment for 4 h,the FIB level in the observation group[(2.56±0.93)g/L]was lower than the control group[(3.41±0.96)g/L,t=3.541,P＜0.05],and the PT,TT and APTT in the observation group[(12.45±2.38),(15.48±2.34),(36.46±4.50)s]were longer than the control group[(10.58±1.86),(13.29±1.67),(29.15±3.92)s,t=3.431,4.216,6.801,P＜0.05].After 7 days of treatment,the levels of serum hs-CRP,TNF-α and MDA in the observation group[(7.85±0.63)mg/L,(126.31±23.56)pg/ml,(5.74±1.37)U/L]were lower than those in the control group[(10.44±0.76)mg/L,(145.93±26.48)pg/ml,(9.88±1.52)U/L,t=14.646,3.086,11.278,P＜0.05],and the level of serum SOD in the observation group[(74.85±10.19)U/ml]was higher than that in the control group[(68.34±9.20)U/ml,t=2.634,P＜0.05].There was no significant difference in the incidence of postoperative complications between the two groups[18.75％(6/32)vs.13.33％(4/30),P＞0.05].Conclusion Interventional embolization in patients with hemorrhagic shock caused by pelvic fracture can reduce the amount of blood transfusion and infusion,shorten the time of shock correction,improve coagu-lation function,alleviate oxidative stress and inflammatory reaction,and has high safety.
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