Predictive value of serum carbohydrate antigen 19-9,carbohydrate antigen 242,and chemokine 20 in combination for postoperative recurrence and metastasis of colon cancer
Objective To analyze the predictive value of serum carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 242(CA242),and chemokine 20(CCL20)in combination for postopera-tive recurrence and metastasis of colon cancer.Methods A total of 112 colon cancer patients admitted to our hospital from September 2019 to December 2021 were collected and divided into a recurrence group and metastasis group(n=34)and non-recurrence and non-metastasis group(n=78)based on follow-up re-cords.Enzyme linked immunosorbent assay(ELISA)was applied to detect the expression levels of serum CA19-9,CA242,and CCL20.Multivariate Logistic regression was applied to analyze the influencing fac-tors of postoperative recurrence and metastasis in colon cancer patients.Receiver operating characteristic(ROC)curve was plotted to analyze the predictive value of serum CA19-9,CA242,and CCL20 in combi-nation for postoperative recurrence and metastasis of colon cancer.Pearson method was applied to analyze the correlation between serum CA19-9,CA242,CCL20 and tumor markers.Results Compared with the non-recurrence and non-metastasis group[(15.32±1.55)U/ml,(6.32±0.92)U/ml,(95.21±10.32)pg/ml],the serum levels of CA19-9[(19.25±2.36)U/ml],CA242[(8.65±1.02)U/ml],and CCL20[(112.65±12.38)pg/ml]in colon cancer patients in the recurrence and metastasis group were obviously increased(t=10.444,11.921,7.730,P＜0.05).There were statistically significant differences in tumor diameter,differentiation degree,TNM staging,and related tumor markers[vascular endothelial growth factor(VEGF),carcinoembryonic antigen(CEA),and hypoxia inducible factor-1α(HIF-1α)]between the two groups(x2=3.973,5.185,t=2.902,20.328,P＜0.05).TNM stage Ⅱ,HIF-1α,CA19-9,CA242,and CCL20 levels were all risk factors for postoperative recurrence and metasta-sis in colon cancer patients[OR=1.325,1.259,1.559,1.452,95％CI=1.047-1.676,1.010-1.569,1.122-2.167,1.049-2.010,P＜0.05].ROC curve results showed that the AUC of CA19-9,CA242,CCL20,and their combined prediction for postoperative recurrence and metastasis of colon cancer was 0.837,0.850,0.855,and 0.940,which was obviously better than the individual prediction of CA19-9(Z=2.280,P＜0.05),CA242(Z=2.110,P＜0.05),and CCL20(Z=3.020,P＜0.01).There was a pairwise positive correlation between serum CA19-9,CA242,and CCL20,and they were also positively correlated with VEGF,CEA,and HIF-1α(r=0.402,0.534,P＜0.05).Conclusion In patients with postoperative recurrence and metastasis of colon cancer,serum levels of CA19-9,CA242,and CCL20 obviously increase,all of which are risk factors affecting postoperative recurrence and metastasis of colon cancer.The combined detection of three factors helps predict postoperative recurrence and metastasis of colon cancer.
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