Developments in the field of exosomes with physical modifications
Exosomes have received significant study interest in the field of biomedicine in recent years,and as the research progresses,their application to clinical diagnosis and therapy has become a hot topic among researchers.Exosomes are extracellular vesicles released by cells that contain nucleic acids,proteins,and other biologically active substances.They play a crucial part in the organism's physiological and pathological processes.Exosomes have a vast and distinct advantage over synthetic carriers such as liposomes and nanoparticles because they are endogenous and di-verse.Exosomes'clinical applicability is limited by their poor storage stability,low yield,low purity,and weak targe-ting.The above problems can be explored and optimized by physical modification.In this paper,by searching a large number of literatures,the latest research progress of various physically-modified exosomes is reviewed,and the future application prospect of exosome modification is prospected.