Advances in etiology of hepatic fibrosis in biliary atresia
Biliary atresia is the most common cause of obstructive jaundice in infants,which is characterized by progressive extrahepatic biliary obstruction and liver fibrosis.Although Kasai procedure can improve the prognosis of some patients,it cannot effectively prevent the progression of liver fibrosis,and most patients still need liver transplan-tation for long-term survival.At present,the mechanism of liver fibrosis in biliary atresia is not completely clear.A new study has found that the occurrence of biliary atresia of liver fibrosis may be related to genetic,biliary dysplasia,virus infection,autoimmune,inflammation response,transformation of epithelial mesenchymal and vascular system and so on factors.This paper summarized the pathogenesis of biliary atresia of liver fibrosis,for future improving the long-term survival of patients with biliary atresia and reducing liver transplantation are of great significance.
Biliary atresiaLiver fibrosisPathogenesisHeredity of genes
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