Research and application progress in mucin in colorectal cancer
Colorectal cancer(RC)is the third most common malignant tumor,with more than 150 000 new ca-ses in 2023 and a mortality rate of 8％in the world.Therefore,it is of great significance for the prevention,identifica-tion,screening and treatment of CRC.Recent studies have shown that intestinal mucus plays an important role in the occurrence and development of gut-related diseases,and mucin,an important component of mucus,can induce the oc-currence of tumors through abnormal methylation and O-glycoylation modification.In this review,the effects of mucins on cell cycle,apoptosis and tumor microenvironment in CRC were reviewed,and the potential value of mucins in prog-nosis assessment and treatment of CRC patients was discussed.The in-depth exploration of mucin will provide a new direction for the pathogenesis of CRC,the search for simple and efficient diagnostic markers and the exploration of CRC treatment.
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