摘要
二酰基甘油激酶(DGK)在调节多种生物过程中扮演着重要角色,通过多种机制调节细胞内的二酰基甘油水平,影响细胞信号转导、细胞生长、膜运输、分化和迁移等多种细胞功能.DGKζ属于DGK家族的一员,通过将二酰基甘油(DAG)磷酸化转化为磷脂酸(PA),在脂质代谢、调节免疫和肿瘤发生发展中起关键调节作用.本文主要就DGKζ的结构及生理功能、在肿瘤发展中的作用,以及相关靶点药物和联合治疗的研究进展作一综述.
Abstract
Diacylglycerol kinase(DGK)plays a significant role in regulating various biological processes by modulating intracellular diacylglycerol levels through multiple mechanisms,affecting cell signaling,growth,membrane transport,differentiation,and migration among various cellular functions.Diacylglycerol kinase ζ(DGKζ),a member of the diacylglycerol kinase family,phosphorylates diacylglycerol(DAG)to convert it into phosphatidic acid(PA),playing a crucial regulatory role in lipid metabolism,immune regulation,and tumor development.This article provides an overview of the structure and physiological functions of DGKζ,its role in tumor development,as well as research progress in relevant targeted drugs and combination therapies.
基金项目
国家自然科学基金项目(32270955)
国家自然科学基金项目(81972869)
江苏省重点研发计划专项资金项目(BE2022719)
江苏省医学重点学科(YXZDXK202236)
NETL
NSTL
万方数据