Research status and prospect of cardiac xenotransplantation
Heart transplantation is considered standard treatment methods for end-stage heart fail-ure,but the lack of donor heart sources seriously restricts the development of heart transplantation.In re-cent years,owing to the improvement of gene-editing technology,a lot of progress has been made in the preclinical investigation of xenografts,which may be a feasible solution to alleviate the shortage of donor hearts.In particular,researchers have been encouraged by the recent success of the world's first gene-edi-ted pig-to-human heart transplant at the University of Maryland Medical Center.The author of this paper summarizes development and special problems,from cardiac xenotransplantation immune rejection,biologi-cal safety,interspecies adaptation,social ethics and health budget,and discusses the prospect of cardiac xenotransplantation clinical trials and challenges,which can expect the future cardiac xenotransplantation into clinical success.
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