Mendelian randomization analysis of the relationship between gut microbiota and aortic aneurysm
Objective To analyze the causal relationship between gut microbiota(GM)and aortic aneurysm(AA)by Mendelian randomization(MR).Methods The data of 196 known human gut micro-biota taxa were downloaded from MiBioGen database as exposure factors whose single nucleotide polymor-phisms(SNP)were acquired as instrument variables(Ⅳ).The data of aortic aneurysms downloaded from the GWAS database including 2 825 patients and 215 067 patients were used as outcome variables.Inverse variance weighted(IVW)was the primary method to analyze relationship in this study.At the same time,MR-Egger regression,simple mode,weighted median and weighted mode were used as supplementary meth-ods for IVW.A series of sensitivity analyses were performed to validate the robustness of the results.Results IVW suggested that class Negativicutes[odds ratio(OR)=1.403,95％confidence interval(CI):1.03-1.901,P＜0.05],order Selenomonadales(OR=1.514,95％CI:1.003-2.284,P＜0.05),genus Parasut-terella(OR=1.297,95％CI:1.059-1.588,P＜0.05)and genus RuminococcaceaeUCG014(OR=1.353,95％CI:1.092-1.677,P＜0.01)played a causal role in enhancing the risk of AA.Whereas phylum Lenti-sphaerae(OR=0.788,95％CI:0.643-0.966,P＜0.05),phylum Verrucomicrobia(OR=0.748,95％CI:0.583-0.960,P＜0.05),class Lentisphaeria(OR=0.780,95％CI:0.622-0.978,P＜0.05),class Verrucomicrobiae(OR=0.612,95％CI:0.449-0.836,P＜0.01),order Bifidobacteriales(OR=0.722,95％CI:0.58-0.896,P＜0.01),order Verrucomicrobiales(OR=0.612,95％CI:0.449-0.836,P＜0.01),order Victivallales(OR=0.780,95％CI:0.622-0.978,P＜0.05),family Bifidobacteriaceae(OR=0.722,95％CI:0.581-0.896,P＜0.01),family Verrucomicrobiaceae(OR=0.612,95％CI:0.449-0.836,P＜0.01),genus Akkermansia(OR=0.612,95％CI:0.449-0.836,P＜0.01),and genus Ruminococcus1(OR=0.752,95％CI:0.578-0.979,P＜0.05)were suggestively inhibitive causal effects on the risk of AA.Conclusion There is a causal relationship between GM and AA.
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