Objective To analyze the causal relationship between gut microbiota(GM)and aortic aneurysm(AA)by Mendelian randomization(MR).Methods The data of 196 known human gut micro-biota taxa were downloaded from MiBioGen database as exposure factors whose single nucleotide polymor-phisms(SNP)were acquired as instrument variables(Ⅳ).The data of aortic aneurysms downloaded from the GWAS database including 2 825 patients and 215 067 patients were used as outcome variables.Inverse variance weighted(IVW)was the primary method to analyze relationship in this study.At the same time,MR-Egger regression,simple mode,weighted median and weighted mode were used as supplementary meth-ods for IVW.A series of sensitivity analyses were performed to validate the robustness of the results.Results IVW suggested that class Negativicutes[odds ratio(OR)=1.403,95％confidence interval(CI):1.03-1.901,P＜0.05],order Selenomonadales(OR=1.514,95％CI:1.003-2.284,P＜0.05),genus Parasut-terella(OR=1.297,95％CI:1.059-1.588,P＜0.05)and genus RuminococcaceaeUCG014(OR=1.353,95％CI:1.092-1.677,P＜0.01)played a causal role in enhancing the risk of AA.Whereas phylum Lenti-sphaerae(OR=0.788,95％CI:0.643-0.966,P＜0.05),phylum Verrucomicrobia(OR=0.748,95％CI:0.583-0.960,P＜0.05),class Lentisphaeria(OR=0.780,95％CI:0.622-0.978,P＜0.05),class Verrucomicrobiae(OR=0.612,95％CI:0.449-0.836,P＜0.01),order Bifidobacteriales(OR=0.722,95％CI:0.58-0.896,P＜0.01),order Verrucomicrobiales(OR=0.612,95％CI:0.449-0.836,P＜0.01),order Victivallales(OR=0.780,95％CI:0.622-0.978,P＜0.05),family Bifidobacteriaceae(OR=0.722,95％CI:0.581-0.896,P＜0.01),family Verrucomicrobiaceae(OR=0.612,95％CI:0.449-0.836,P＜0.01),genus Akkermansia(OR=0.612,95％CI:0.449-0.836,P＜0.01),and genus Ruminococcus1(OR=0.752,95％CI:0.578-0.979,P＜0.05)were suggestively inhibitive causal effects on the risk of AA.Conclusion There is a causal relationship between GM and AA.
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