目的 系统评价国内外肝硬化患者抑郁症状的发病率。方法 我们使用计算机检索Web of Science、PubMed、Embase、万方数据库、中国知网和维普数据库，收集关于国内外肝硬化患者抑郁症状发病率的文献，检索时限为从建库开始至2024年3月，然后利用上述数据库收集相关文献。按照规范要求两名研究者独立进行文献筛选、数据提取，并评估纳入文献的偏倚风险。确定最终纳入的文献后，我们采用R4。3。3软件进行Meta分析。结果 根据一系列步骤共纳入48篇文献，包括308 918例肝硬化患者，其中73 187例发生抑郁症状，国内外肝硬化患者抑郁症状的发病率为49。1％[95％可信区间(CI):42。4％～55。8％]。亚组分析结果显示，研究地域为国内、横断面研究、年龄＜60岁、有并发症、筛查工具为SDS的患者抑郁症的患者抑郁症状发病率更高。结论 肝硬化患者抑郁症状的发病率较高。医护人员应加强对肝硬化患者抑郁的筛查与评估，及时采取相应的干预措施，以改善患者不良情绪。
A comprehensive study on the incidence of depression in cirrhotic patients
Objective To systematically evaluate the incidence of depressive symptoms in cirrhotic patients at home and abroad.Methods PubMed,Embase,Web of Science,CNKI,Wanfang Database and VIP database were searched by computer to collect literature on the incidence of depressive symptoms in cirrhotic patients at home and abroad.The search time was from the inception of the database to March 2024.Two researchers independently screened the literature,extracted data,and evaluated the risk of bias in the included literature,and then conducted a Meta-analysis using R4.3.3 software.Results According to a series of steps,a total of 48 articles were included,including 308,918 patients with cirrhosis,of whom 73,187 developed depressive symptoms,and the incidence of depressive symptoms in cirrhotic pa-tients was 49.1％[95％confidence interval(CI):42.4％-55.8％].Subgroup analysis showed that inci-dence of depressive symptoms was higher in patients with depression who were domestic,cross-sectional,aged＜60 years,had complications,and were screened with SDS.Conclusion The incidence of depres-sive symptoms is higher in patients with cirrhosis.Medical workers should strengthen the screening and e-valuation of depression in patients with cirrhosis,and take corresponding intervention measures in time to improve the adverse mood of patients.
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万方数据
