首页|术前白蛋白-胆红素对胃癌术后生存预测价值

术前白蛋白-胆红素对胃癌术后生存预测价值

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目的 探讨术前白蛋白-胆红素(ALBI)分级在胃癌患者术后生存率中的预测价值。方法 选取2020年3月至2022年3月镇江市第一人民医院胃癌根治术患者135例,根据ALBI分级将其分为ALBI 1级组98例、ALBI 2级组37例。比较两组临床病理特征,采用Kaplan-Meier法进行生存分析,比较不同ALBI分级的1年生存率差异,采用COX比例风险回归模型分析胃癌术后远期生存率的影响因素。结果 ALBI 1级生存率高于ALBI 2级[89。80%(88/98)比70。27%(26/37),x2=8。159,P<0。05]。ALBI 分级[风险比(HR)=2。840]、分化程度(HR=1。728)、肿瘤分期(HR=1。764)、CEA水平(HR=1。586)、术后辅助化疗(HR=1。784)是影响胃癌根治术患者预后的独立影响因素(P<0。01)。结论 术前ALBI分级用于评估胃癌根治术患者手术风险及预后结局较为可行,具有一定预测价值。
Predictive value of preoperative albumin-bilirubin for postoperative survival of gastric cancer
Objective To explore the predictive value of preoperative albumin-bilirubin(ALBI)grading in the postoperative survival rate of patients with gastric cancer.Methods From March 2020 to March 2022,135 patients with gastric cancer undergoing radical gastrectomy in the First People's Hospital of Zhenjiang City were selected.According to ALBI classification,98 patients were fallen into ALBI grade 1 group and 37 patients into ALBI grade 2 group.The clinicopathological features of the two groups were compared.Kaplan-Meier method was used for survival analysis.The 1-year survival rate of different ALBI grades was compared.COX proportional hazard regression model was used to analyze the influencing factors of long-term survival rate after gastric cancer surgery.Results The survival rate of ALBI grade 1 was higher than that of ALBI grade 2[89.80%(88/98)vs.70.27%(26/37),x2=8.159,P<0.05].The survival rate of ALBI grade 1 was 89.80%,higher than that of ALBI grade 2(70.27%,P<0.05).ALBI grade[hazard ratio(HR)=2.840],differentiation degree(HR=1.728),tumor stage(HR=1.764),CEA level(HR=1.586),and postoperative adjuvant chemotherapy(HR=1.784)were independent influen-cing factors for the prognosis of patients undergoing radical gastrectomy(P<0.01).Conclusion Preopera-tive ALBI grading is feasible to evaluate the surgical risk and prognosis of patients undergoing radical gastrec-tomy and has certain predictive value.

Radical gastrectomy for gastric cancerAlbuminBilirubinSurgical risksPrognosis

白璐、侯雯跻、党胜春、沈耀、殷凯

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镇江市第一人民医院重症医学科,镇江 212002

镇江市第一人民医院普外科,镇江 212002

江苏大学附属医院普外科,镇江 212001

南通市海门区人民医院普外科,南通 226100

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胃癌根治术 白蛋白 胆红素 手术风险 预后

镇江市科技计划项目国家自然科学基金

SH202103582370533

2024

中华实验外科杂志
中华医学会

中华实验外科杂志

CSTPCD
影响因子:0.759
ISSN:1001-9030
年,卷(期):2024.41(8)