The expression and clinical significance of zinc finger protein zinc finger protein 692 in colorectal cancer
Objective To investigate the correlation between zinc finger protein 692(ZNF692)as a potential oncogene and the prognosis of patients with colon cancer.Methods Tissue microarray and im-munohistochemistry(IHC)staining technique were used to detect the expression of ZNF692 protein in 248 cases of colon cancer formalin-fixed and paraffin-embedded(FFPE)sections.At the same time,the data of 176 cases of colorectal cancer in the cancer genome atlas(TCGA)database were analyzed and veri-fied by R language.Wilcoxon rank sum test was used to compare the expression of ZNF692 in tumor tissues and normal tissues,x2 test was used to analyze the correlation between the expression of ZNF692 and clini-copathological indexes,and K-M curve method and COX multivariate regression were used to analyze the prognostic factors of colon cancer patients.Results The expression level of ZNF692 in tumor was signifi-cantly higher than that in adjacent normal tissues(1.49±0.07 vs.0.27±0.14,P＜0.05).There was no significant difference in sex,T stage,N stage,nerve and/or vascular invasion between the low expression group and the high expression group.However,there were significant differences in age,M stage and dif-ferentiation between the two groups(P＜0.05).Multivariate analysis showed that high expression of ZNF692 was an independent risk factor for poor prognosis of colon cancer patients[P＜0.05,HR=1.859,95％confidence interval(CI)=1.18-3.36].The average survival(months)in low ZNF692 expression group was longer than that in high expression group[(47.58±1.36)months vs.(38.83±1.57)moths,P＜0.05].Bioinformatics analysis also confirmed that the expression level of ZNF692 affected the progno-sis of patients with colorectal cancer.Conclusion The high expression of ZNF692 is obviously related to the age,differentiation and distant metastasis of colorectal cancer patients,and the survival time of patients with high expression of ZNF692 is shorter.
Zinc finger protein 692Colorectal cancerBioinformaticsTissue microarrayPrognosis
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