Effect of different surgical procedures on hypertensive intracerebral hemorrhage in the basal ganglion and their effect on inflammation and neurological function
Objective To investigate the effect of neuroendoscopy and traditional craniotomy on hypertensive intracerebral hemorrhage in the basal ganglion and their effect on inflammation and neurologi-cal function.Methods A total of 82 patients with initial hypertensive intracerebral hemorrhage in the bas-al ganglion and treated in the First People's Hospital of Shangqiu City from October 2021 to May 2023 were selected,and all patients were divided into control group(41 cases)and observation group(41 cases)u-sing the random number table method.The control group was given traditional craniotomy haematoma re-moval and the observation group was given neuroendoscopy.Intraoperative haemorrhage,haematoma clear-ance,and postoperative complication rates were compared between the two groups.Tumor necrosis factor-α(TNF-α),interleukin(IL)-6,and IL-1β enzyme linked immunosorbent assay(ELISA)kits were used to detect postoperative TNF-α,IL-6,and IL-1β serum levels.Postoperative serum levels of S100 and neuron specific enolase(NSE)were measured using electrochemiluminescence kits.The NIHSS scores were used to evaluate the neurological dysfunction of cerebral hemorrhage patients,and GCS was used to evaluate the consciousness level of patients with cerebral hemorrhage.Independent sample t test was used to compare the measurement data between groups.Results The haematoma clearance rate[(90.02±3.95)％]of patients in the observation group was significantly higher than that in the control group[(82.07±5.16)％],and the intraoperative bleeding volume[(33.70±4.16)ml]and postoperative concurrent inci-dence rate[4.88％(2/41)]were significantly lower in the observation group than in the control group[(49.67±5.70)ml,21.95％(9/41),t=7.83,14.49,5.15,P＜0.05].At 3rd day after surgery,the serum TNF-α[(249.41±20.38)pg/ml],IL-6[(65.56±6.35)pg/ml],and IL-1β[(201.77±19.84)pg/ml]levels in the observation group were significantly lower than those in the control group[(312.77±24.20),(88.40±7.37),(284.31±19.27)pg/ml,t=12.82,15.03,19.11,P＜0.05].At 3rd day after surgery,the serum S100[(0.29±0.03)µg/L]and NSE[(26.31±3.70)ng/ml]levels in the observation group were significantly lower than those in the control group[(0.35±0.04)µg/L,(32.97±4.57)ng/ml,t=8.83,7.25,P＜0.05].There was no significant difference in NIHSS score[(28.27±2.39),(28.78±2.07)points]and GCS score[(7.80±1.75),(8.05±1.61)points]be-tween the observation group and control group before treatment(t=1.04,0.66,P＞0.05).After treat-ment,the NIHSS score[(15.15±1.13)points]in the observation group was significantly lower than that in the control group[(18.17±1.86)points],while the GCS score[(15.07±1.98)points]was signifi-cantly higher in the observation group than that in the control group[(12.07±1.59)points,t=8.91,7.57,P＜0.05].Conclusion Neuroendoscopy has good haematoma removal effect,reduces the amount of intraoperative haemorrhage,the incidence of postoperative complications and the level of inflammation in patients,and improves the postoperative neurological deficits in patients.
NeuroendoscopyHypertensive intracerebral hemorrhageInflammatory factorNeurological function
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