Effect of pulsed radiofrequency combined with repetitive transcranial magnetic stimulation on postherpetic neuralgia
Objective To observe the efficacy and safety of peripheral nerve pulse radiofrequency(PRF)combined with repetitive transcranial magnetic stimulation(rTMS)in the treatment of long-term pain caused by postherpetic neuropain(PHN),and to provide a new idea and method for the treatment of PHN.Methods From April 2021 to January2023,100 patients with PHN were randomly divided into PRF group(n=50)and combined group(n=50).The PRF group was treated with PRF(65 V)guided by muscle bone ultrasound(MBU),and the combined group was treated with rTMS(10 Hz)on the basis of PRF group.The clinical efficacy,adverse reactions and visual simulation scale(VAS),Pittsburgh sleep quality index(PSOI),quality of life scale(SF-36)and self-rating depression scale(SDS)before treatment(T0),1 week after treatment(T1),1 month after treatment(T2)and 3 months after treatment(T3)were compared between the two groups.The scores of VAS,PSOI,SF-36,SDS in both groups at T0,T1,T2,T3 were analyzed by double factor repeated measurement variance analysis.Results The total effective rate of the combined group was significantly higher than that of the PRF group(96.0％vs.86.0％,x2=11.520,P＜0.05).The scores of VAS(5.06±0.25 vs.6.15±0.22,F=2.265,P＜0.01;2.26±0.32 vs.4.33±0.21,F=1.034,P＜0.01;1.35±0.11 vs.2.61±0.08,F=2.024,P＜0.01),PSOI(10.55±0.78 vs.12.09±0.96,F=1.411,P＜0.01;8.65±0.87 vs.9.98±0.56,F=3.031,P＜0.01;7.56±0.22 vs.8.74±0.15,F=6.888,P＜0.01),and SDS(43.76±4.52 vs.45.61±3.21,F=2.783,P＜0.01;40.82±1.26 vs.41.95±0.53,F=6.514,P＜0.01;28.21±0.42 vs.31.70±0.17,F=2.468,P＜0.01)in the combined group were significantly lower than those in the con-trol group,while the scores of SF-36(78.24±5.36 vs.75.66±1.25,F=5.418,P＜0.01;80.23±1.02 vs.79.27±5.41,F=2.177,P＜0.01;85.24±1.42 vs.81.23±1.24,F=3.926,P＜0.01)were significantly higher than those in the control group.Conclusion MBU guided peripheral nerve PRF combined with rTMS is effective in the treatment of PHN,which can reduce the degree of pain and depres-sion,improve the quality of sleep and quality of life,and is safer than PRF alone.
Postherpetic neuropainPulse radiofrequencyRepetitive transskull magnetic stimulationUltrasound
NETL
NSTL
万方数据
