Expression and clinical significance of progranulin and GATA binding factor-6 in glioma tissues
Objective To investigate the relationship between the expression of progranulin(PGRN)and GATA binding factor-6(GATA6)in glioma tissue and clinicopathological features and prog-nosis.Methods A total of 84 patients with glioma admitted to Huaihe Hosiptal of Henan University from January 2017 to March 2019 were used as subjects.Glioma tissue and adjacent tissue specimens were col-lected and followed up for 5 years.Immunohistochemical methods were applied to detect the expression of PGRN and GATA6 proteins in tissues.The relationship between the expression of PGRN and GATA6 in glioma tissue and clinical pathological characteristics is expressed as n(％),and a chi square test is per-formed.Multivariate Cox regression was applied to analyze the prognostic factors of glioma patients.Kap-lan-Meier method was applied to analyze the relationship between the expression of PGRN and GATA6 in the tissues of glioma patients and their prognosis.Results The positive expression rate of PGRN in glioma tissues was higher than that in adjacent tissues(73.81％vs.40.48％,x2=19.056,P＜0.05),and the positive expression rate of GATA6 in glioma tissues was higher than that in adjacent tissues(69.05％vs.36.90％,x2=17.419,P＜0.05).The positive expression rates of PGRN(83.33％,90.63％)and GATA6(79.63％,84.38％)in patients with WHO grades Ⅲ-Ⅳ and low differentiation were higher than those in patients with WHO grades Ⅰ-Ⅱ(56.67％,50.00％)and high differentiation(63.46％,59.62％,x2=7.094,7.922,7.561,5.682,P＜0.05).The 5-year survival rate of patients with PGRN positive expression in glioma tissue was lower than that of patients with PGRN negative expression(32.26％vs.77.27％,x2=13.351,P＜0.05).The 5-year survival rate of GATA6 positive expression patients was lower than that of GATA6 negative expression patients(31.03％vs.73.08％,x2=12.875,P＜0.05).PGRN[hazard ratio(HR)=2.398,95％confidence interval(CI):1.369-4.200]and GATA6(HR=2.843,95％CI:1.426-5.668)were independent risk factors for mortality in glioma patients(HR=2.398,2.843,P＜0.05).Conclusion The positive expression rates of PGRN and GATA6 in glioma tissues are relatively high,which are related to the pathological features and prognosis of glioma patients,and they are independent risk factors for mortality in glioma patients.
GliomaProgranulinGATA binding factor-6PrognosisClinical pathological features
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