Changes of serum energy metabolism in patients with intracranial infection after neurosurgery and its clinical significance
Objective To investigate the changes of energy metabolism in patients with intracranial infection after neurosurgery and its clinical significance.Methods A total of 90 patients with intracranial infection who received surgical treatment in the Neurosurgery Department of our hospital from June 2021 to June 2024 were selected as the experimental group,and divided into three groups:mild infection group,moderate infection group and severe infection group according to the results of biochemical examinations.A total of 50 patients without intracranial infection after craniotomy were selected as the control group.Lactic acid(LAC),procalcitonin(PCT)and highly sensitive C-reactive protein(hs-CRP)detection kits were used to detect serum LAC,PCT and CRP levels in all patients.The serum LAC,CRP and PCT levels in the control group and the experimental group were compared and analyzed.The levels of serum LAC,CRP and PCT in mild infection group,moderate infection group and severe infection group were compared and analyzed.Glasgow coma scale(GCS)was used to evaluate the mental status and prognosis of mild infection group,moderate infection group and severe infection group.Pearson correlation analysis was used to evalu-ate the relationship between serum LAC and PCT,CRP and GCS scores.Results The levels of serum LAC[(4.18±1.31)mmol/L],CRP[(238.94±76.05)pg/ml]and PCT[(330.74±100.40)pg/ml]in experimental group were significantly higher than those in control group[(1.92±0.15)mmol/L,(83.75±12.97)pg/ml,(115.13±16.72)pg/ml,t=12.11,14.29,15.05,P＜0.05].The levels of serum LAC[(4.22±0.48)mmol/L],CRP[(237.89±30.34)pg/ml]and PCT[(324.38±51.54 pg/ml]in moderate infection group were significantly higher than those in mild infection group[(2.70±0.44)mmol/L,(157.96±26.82)pg/ml,(226.49±39.33)pg/ml,t=12.66,10.81,8.23,P＜0.05].The levels of serum LAC[(5.63±0.66)mmol/L],CRP[(320.96±48.66)pg/ml]and PCT[(441.35±52.80)pg/ml]in severe infection group were significantly higher than those in moderate infection group(t=9.48,7.94,8.68,P＜0.05).The GCS score in moderate infection group[(9.50±0.94)points]was significantly lower than that in mild infection group[(12.10±1.12)points,t=9.72,P＜0.05],and that in severe infection group[(7.50±1.00)points]was significantly lower than that in moderate infection group(t=7.95,P＜0.05).Serum LAC levels were positively correlated with CRP and PCT levels(r=0.76,0.81,P＜0.05),and negatively correlated with GCS score(r=-0.79,P＜0.05).Conclusion The serum level of LAC in patients with intracranial infection after neurosurgery was significantly upregulated,and was positively correlated with the severity of infection and negatively correla-ted with the prognosis of patients,which could provide important value for the early diagnosis and prognosis assessment of intracranial infection after neurosurgery.
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