Diagnostic value of microRNA-183 and microRNA-26a for colon cancer and their correlation with prognosis
Objective To explore the diagnostic value of serum microRNA(miR)-183 and miR-26a for colon cancer and their correlation with prognosis.Methods Totally,109 colon cancer patients with follow-up outcomes admitted to the Affiliated People's Hospital of Shandong First Medical University were selected as the study subjects(colon cancer group),including 62 male patients and 47 female pa-tients,with an average age of(63.5±7.3)years.A total of 100 patients diagnosed as having colon polyps through colonoscopy were used as the control group,with 55 male patients and 45 female patients,with an average age of(61.8±8.0)years.The serum levels of miR-183 and miR-26a were determined and com-pared between two groups.The receiver operating characteristic(ROC)curve was drawn to analyze the val-ue of these two indicators in diagnosing colon cancer.According to the 3-year follow-up results,the colon cancer group was divided into a survival subgroup(n=69 cases)and a death subgroup(n=40 cases).Univariate and multivariate analysis methods were used to analyze the relationship between serum miR-183,miR-26a and patient prognosis.The data uses independent samples t-test,x2 test and logistic regression to analyze the independent risk factors of poor prognosis of colon cancer patients within 3 years.Results The serum miR-183(2.68±0.64)of patients with colon cancer was significantly higher than that of the control group(1.08±0.32),and the serum miR-26a(1.14±0.23)was lower than that of the control group(2.19±0.43),with statistically significant differences(t=22.545,-22.261,P＜0.05).The area un-der curve(AUC)value of serum miR-183 for differential diagnosis of colon cancer and colon polyps was 0.849,and that of miR-26a for differential diagnosis of colon cancer and colon polyps was 0.817(P＜0.05).The serum miR-183(3.11±0.58)of colon cancer patients in the death subgroup was significantly higher than that in the survival subgroup(2.43±0.61),and the serum miR-26a in the death subgroup(0.80±0.17)was lower than that in the survival subgroup(1.34±0.20).The differences were statisti-cally significant(t=-5.710,14.330,P＜0.05).The results of the logistic regression model showed that pathological staging(stages Ⅲ-Ⅳ),occurrence of lymph node metastasis,vascular invasion,elevated serum miR-183 levels,and decreased miR-26a levels were independent risk factors for 3-year poor progno-sis in colon cancer patients[The odds ratio(OR)values were 1.848,1.941,2.020,1.644,and 0.515,respectively,P＜0.05].Conclusion Elevated serum miR-183 levels and decreased miR-26a levels in colon cancer patients have important value in clinical differential diagnosis of colon cancer and colon polyps,and are closely related to patient prognosis.
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