Application of patient derived tumor xenograft models in pancreatic cancer research
Pancreatic cancer is a malignant tumor with a high degree of malignancy,insidious onset and very poor prognosis,and the systemic comprehensive treatment represented by chemotherapy is still the main means to im-prove the postoperative prognosis of pancreatic cancer patients.However,the drug resistance mechanism of pancreatic cancer is complex,there are many chemotherapy regimens to choose from,and patients have different sensitivities and efficacy of each chemotherapy regimen,so a preclinical model is needed to test the effectiveness of each chemotherapy drug and screen out the most suitable drug for patients.By implanting the patient's tumor tissue into immunodeficient mice to generate an individualized patient derived tumor xenografts model,the patient is guided to clinical medication.Based on reviewing the PDX model establishment method for pancreatic cancer,this article will review the application progress of PDX model in the field of pancreatic cancer treatment,aiming to provide a new direction for the individual-ized treatment of pancreatic cancer.
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