Research progress in small molecules and biomateials for treating intervertebral disc degeneration
Intervertebral disc degeneration(IDD)is the main cause of chronic low back pain,and how to de-lay and treat IDD has been a clinical challenge.In recent years,many drugs have shown good therapeutic effects on IDD in basic research.However,due to the involvement of various cells such as nucleus pulposus cells(NPCs),stem cells,fibroblasts,and other factors such as inflammation and apoptosis,the mechanism of IDD is very complex,which also makes these drugs have not been successfully applied in the clinic.In addition,the poor blood supply to interver-tebral discs reduces the duration of maintaining effective drug concentrations,so improving drug carriers is also an im-portant part of treating IDD.This article summarizes the potential drugs,biomaterials,and mechanisms discovered by many scholars in recent years for the treatment of IDD,hoping to provide reference for subsequent research.
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