Neutrophils and tumor liver metastasis:from bench to bedside
Tumor liver metastasis,as one of the common modes of malignant tumor metastasis,lacks effective therapies,leading to extremely poor patient prognosis.With the advancement of experimen-tal detection technologies,the traditional concept of neutrophils as single-function immune cells has been gradually revised;neutrophils have been found to be an abundantly heterogeneous cell population that plays diverse roles in regulating tumor biological behavior.Massive and rapid infiltration into the liver at the ini-tial stage of metastasis,flexible functional plasticity,and natural chemotactic ability make tumor-associated neutrophils highly valuable for basic research and target potential in liver metastasis.This article focuses on the current status of experimental studies on neutrophils in tumor liver metastasis,discusses and looks for-ward to potential clinical therapeutic strategies for targeting neutrophils.
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