摘要
胰腺癌恶性程度高、早期诊断困难、治疗进展缓慢.铁死亡、焦亡和坏死性凋亡等新型调节性细胞死亡在胰腺癌发生发展中的作用及其机制研究是前沿热点问题.近年,一些研究结果显示肿瘤微环境对肿瘤细胞死亡过程具有重要调控作用,同时,不少研究初步揭示了肿瘤细胞死亡对肿瘤微环境的复杂影响.本文将围绕胰腺癌细胞铁死亡、焦亡和坏死性凋亡等新型细胞死亡与肿瘤微环境之间的相互关系为主题,归纳已有研究进展与不足、指出未来研究问题和方向,希望以此夯实胰腺癌诊治模式革新的理论依据,促进相关基础和临床转化研究.
Abstract
Pancreatic cancer is a highly malignant disease with a difficult early detection and slug-gish treatment progression.The roles of novel regulated cell death,such as ferroptosis,pyroptosis,and ne-croptosis,in the development and progression of pancreatic cancer are research frontiers and hotspots.In recent years,some researchers have discovered that the tumor microenvironment plays an essential regulato-ry function in tumor cell death processes,and many other studies have revealed the impact of tumor cell death on the tumor environment.This review will focus on the interplay between the tumor microenviron-ment and novel cell death modes,including ferroptosis,pyroptosis,and necroptosis,in pancreatic cancer.We will summarize current research findings along with their limitations,and highlight future challenges and directions for investigation.We hope this will strengthen the theoretical framework for innovative diag-nostic and therapeutic strategies targeting pancreatic cancer,and promote related basic and clinical transla-tional research.
NETL
NSTL
万方数据