The interplay between cell death and tumor microenvironment in pancreatic cancer:current status and future perspectives
Pancreatic cancer is a highly malignant disease with a difficult early detection and slug-gish treatment progression.The roles of novel regulated cell death,such as ferroptosis,pyroptosis,and ne-croptosis,in the development and progression of pancreatic cancer are research frontiers and hotspots.In recent years,some researchers have discovered that the tumor microenvironment plays an essential regulato-ry function in tumor cell death processes,and many other studies have revealed the impact of tumor cell death on the tumor environment.This review will focus on the interplay between the tumor microenviron-ment and novel cell death modes,including ferroptosis,pyroptosis,and necroptosis,in pancreatic cancer.We will summarize current research findings along with their limitations,and highlight future challenges and directions for investigation.We hope this will strengthen the theoretical framework for innovative diag-nostic and therapeutic strategies targeting pancreatic cancer,and promote related basic and clinical transla-tional research.
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