Objective To observe the occurrence of laryngopharyngeal reflux(LPR)during pain-less gastroscopy in patients with reflux esophagitis(RE)diagnosed by painless gastroscopy and to explore the risk factors for LPR,as well as to construct a risk prediction model for LPR.Methods A prospective cohort study was conducted among patients scheduled for painless gastroscopy at the First Affiliated Hospital of Zhengzhou University from September 2023 to September 2024.Patients with RE confirmed by gastrosco-py were included as study subjects.At the time of anesthesia assessment,general patient information was collected using interviews.During the painless gastroscopy,exposure information potentially related to LPR occurrence was collected,and the occurrence of LPR was recorded.In the univariate analysis,the chi-square test was used to explore the correlation of factors with the occurrence of LPR.Multivariate Logistic regression analysis was used to explore the risk factors for LPR.Based on the Logistic regression results,a prediction model was established,and the receiver operating characteristic(ROC)curve was plotted to cal-culate the area under the curve(AUC),sensitivity,and specificity.Results Complete data were collect-ed from 1 703 patients with RE confirmed by gastroscopy,among which the incidence of LPR was 8.13％.Univariate analysis showed that age,gender,BMI,smoking history,esophageal hiatus hernia under endos-copy,relaxation of the cardia under endoscopy,esophageal iodine staining,residual gastritis under endos-copy,full stomach,coughing,respiratory depression(x2=186.327,4.414,81.203,53.951,71.724,26.581,9.664,1.810,7.310,4.232,P＜0.05)were correlated with LPR occurrence during painless gastroscopy.Multivariate Logistic regression analysis revealed that BMI overweight,BMI obesity,visible e-sophageal hiatus hernia under endoscopy,age＞66 years[RR=2.991,2.017,1.981,7.635,95％con-fidence interval(CI):1.794-4.988,1.078-3.774,1.228-3.194,2.873-20.291,P＜0.05]were risk factors for LPR.The ROC curve results showed that the area under the ROC curve(AUC)was 0.828,95％CI:0.792-0.864(P＜0.05),with a model sensitivity of 71.090％and specificity of 82.520％.Conclusion There are multiple factors influencing the occurrence of LPR during painless gastroscopy.The LPR risk prediction model can assist clinicians in early planning and management to reduce the inci-dence of LPR.
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