巨噬细胞在骨关节炎疼痛机制中的研究进展
Research progress of macrophages in the pain mechanisms of osteoarthritis
孙卢溪 1刘佳硕 1谢雪涛1
作者信息
- 1. 上海交通大学医学院附属第六人民医院骨科,上海 200233
- 折叠
摘要
骨关节炎(OA)是常见的慢性关节病,主要临床症状是关节疼痛和活动受限.治疗OA的主要目的是缓解疼痛,然而目前手段有限、疗效欠佳,迫切需要更为有效的方法.巨噬细胞是体内重要的免疫细胞,具有清除病原体、参与免疫应答和抗衰老等功能.近年来,随着对OA疼痛机制的不断探索,越来越多的证据表明巨噬细胞在OA疼痛的外周神经机制和中枢神经机制中发挥重要作用,靶向巨噬细胞逐渐成为治疗OA疼痛的潜在方向.本文综述了近年来巨噬细胞在OA疼痛机制中的作用及治疗前景的研究进展.
Abstract
Osteoarthritis(OA)is a common chronic joint disease,whose main symptoms are joint pain and limitation of movement.Relieving pain is the primary purpose of the clinical treatment for OA.It is urged to explore more effective ways as the methods currently mastered by us are limited both in quantity and efficacy.Macrophages are significant immune cells in human body,which have multiple functions like eliminating pathogens,participating in im-mune response and anti-aging.With the continuous researches in recent years,more and more evidences show that macrophages play an important role in both the peripheral and central mechanisms of OA pain,and targeting macropha-ges has gradually become a potential direction for the treatment.This article reviews the recent progress of macrophages in OA pain mechanisms and its therapeutic prospects.
关键词
骨关节炎/疼痛/巨噬细胞Key words
Osteoarthritis/Pain/Macrophage引用本文复制引用
出版年
2024
NETL
NSTL
万方数据